Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2056
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Adra2a
Name: adrenoceptor alpha 2A
Acc ID: CHEBI:10093
Term: yohimbine
Definition: An indole alkaloid with alpha2-adrenoceptor antagonist activity. It is produced by Corynanthe johimbe and Rauwolfia serpentina.
Chemical ID: MESH:D015016
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Adra2amultiple interactionsEXP 6480464CTDYohimbine binds to and results in decreased activity of ADRA2A proteinPMID:8397342
Adra2amultiple interactionsISOAdra2a (Mus musculus)6480464CTDYohimbine binds to and results in decreased activity of ADRA2A proteinPMID:17666864
Adra2amultiple interactionsISOADRA2A (Homo sapiens)6480464CTDYohimbine inhibits the reaction [Brimonidine Tartrate promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA2A protein]]; Yohimbine inhibits the reaction [Norepinephrine binds to and results in increased activity of ADRA2A protein]PMID:10742289
Go Back to source page   Continue to Ontology report