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GENE - TERM ANNOTATION REPORT

RGD ID: 18913436
Species: Heterocephalus glaber
RGD Object: Gene
Symbol: Casp8
Name: caspase 8
Acc ID: GO:0070266
Term: necroptotic process
Definition: A programmed necrotic cell death process which begins when a cell receives a signal (e.g. a ligand binding to a death receptor or to a Toll-like receptor), and proceeds through a series of biochemical events (signaling pathways), characterized by activation of receptor-interacting serine/threonine-protein kinase 1 and/or 3 (RIPK1/3, also called RIP1/3) and by critical dependence on mixed lineage kinase domain-like (MLKL), and which typically lead to common morphological features of necrotic cell death. The process ends when the cell has died. The process is divided into a signaling phase, and an execution phase, which is triggered by the former.
Definition Source(s): GOC:BHF, GOC:dph, GOC:mah, GOC:mtg_apoptosis, GOC:tb, PMID:18846107, PMID:20823910, PMID:21737330, PMID:21760595, PMID:21876153
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp8acts_upstream_ofISOMGI:104798 or MGI:1336166 or MGI:21549529068941MGI PMID:21368763

PMID:21368763
Casp8acts_upstream_ofISOMGI:104798 or MGI:19215069068941MGI PMID:22037414

PMID:22037414
Casp8acts_upstream_ofISOMGI:21549529068941MGI PMID:21402742

PMID:21402742
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