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GENE - TERM ANNOTATION REPORT

RGD ID: 18523466
Species: Chlorocebus sabaeus
RGD Object: Gene
Symbol: PRF1
Name: perforin 1
Acc ID: GO:0044194
Term: cytolytic granule
Definition: A specialized secretory lysosome that is present in cells with cytolytic capability such as cytotoxic T lymphocytes and natural killer cells. Cytolytic granules mediate the storage and regulated excretion of lytic molecules for killing of target cells.
Definition Source(s): GOC:jl, PMID:11052265, PMID:12766758
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PRF1located_inISOPRF1 (Homo sapiens)9068941UniProt PMID:24088571 PMID:9756476

PMID:24088571 PMID:9756476
PRF1located_inISOPrf1 (Mus musculus)9068941UniProt MGI:66009 PMID:8164737 PMID:19915045

MGI:66009 PMID:19915045 PMID:8164737
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