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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1624042
Species: Mus musculus
RGD Object: Gene
Symbol: Dkkl1
Name: dickkopf-like 1
Acc ID: CHEBI:5000
Term: fenfluramine
Definition: A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
Chemical ID: MESH:D005277
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dkkl1increases expressionISODKKL1 (Homo sapiens)6480464CTDFenfluramine results in increased expression of DKKL1 mRNAPMID:22140631
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