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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1623894
Species: Mus musculus
RGD Object: Gene
Symbol: Ppfia3
Name: protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ppfia3decreases expressionEXP 6480464CTDBenzo(a)pyrene results in decreased expression of PPFIA3 mRNAPMID:15034205
Ppfia3affects methylationISOPPFIA3 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of PPFIA3 5' UTR; Benzo(a)pyrene affects the methylation of PPFIA3 intronPMID:27901495 PMID:30157460
Ppfia3increases methylationISOPPFIA3 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of PPFIA3 3' UTR; Benzo(a)pyrene results in increased methylation of PPFIA3 promoterPMID:27901495
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