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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1592081
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mpo
Name: myeloperoxidase
Acc ID: CHEBI:53490
Term: N-formyl-L-methionyl-L-leucyl-L-phenylalanine
Definition: A tripeptide composed of L-Met, L-Leu and L-Phe in a linear sequence with a formyl group at the amino terminus. It acts as a potent inducer of leucocyte chemotaxis and macrophage activator as well as a ligand for the FPR receptor.
Chemical ID: MESH:D009240
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mpoincreases activityISOMPO (Homo sapiens)6480464CTDN-Formylmethionine Leucyl-Phenylalanine results in increased activity of MPO proteinPMID:22906169
Mpoincreases expressionISOMpo (Mus musculus)6480464CTDN-Formylmethionine Leucyl-Phenylalanine results in increased expression of MPO proteinPMID:17159805
Mpoincreases secretionISOMPO (Homo sapiens)6480464CTDN-Formylmethionine Leucyl-Phenylalanine results in increased secretion of MPO proteinPMID:16601795 PMID:18987595
Mpomultiple interactionsISOMpo (Mus musculus)6480464CTDcarvedilol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of MPO protein]PMID:17159805
Mpomultiple interactionsISOMPO (Homo sapiens)6480464CTDcarvedilol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased secretion of MPO protein]; diphenyleneiodonium inhibits the reaction [manganese chloride promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased activity of MPO protein]]; manganese chloride promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased activity of MPO protein]; Sodium Azide inhibits the reaction [manganese chloride promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased activity of MPO protein]]; wortmannin inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased secretion of MPO protein]PMID:16601795 PMID:18987595 PMID:22906169
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