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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1592081
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mpo
Name: myeloperoxidase
Acc ID: CHEBI:34631
Term: chlorpyrifos
Definition: An organic thiophosphate that is O,O-diethyl hydrogen phosphorothioate in which the hydrogen of the hydroxy group has been replaced by a 3,5,6-trichloropyridin-2-yl group.
Chemical ID: MESH:D004390
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mpoincreases activityEXP 6480464CTDChlorpyrifos results in increased activity of MPO proteinPMID:27268782 PMID:28373059 PMID:30267645
Mpoincreases expressionEXP 6480464CTDChlorpyrifos results in increased expression of MPO proteinPMID:34678318
Mpomultiple interactionsEXP 6480464CTD3-(indol-3-yl)propionic acid inhibits the reaction [Chlorpyrifos results in increased expression of MPO protein]; [Chlorpyrifos co-treated with carbendazim] results in increased activity of MPO protein; diphenyldiselenide inhibits the reaction [Chlorpyrifos results in increased activity of MPO protein]; gingerol inhibits the reaction [Chlorpyrifos results in increased activity of MPO protein]PMID:27268782 PMID:28373059 PMID:30267645 PMID:34678318
Mpoincreases activityISOMPO (Homo sapiens)6480464CTDChlorpyrifos results in increased activity of MPO proteinPMID:26519479
Mpoincreases expressionISOMpo (Mus musculus)6480464CTDChlorpyrifos results in increased expression of MPO mRNAPMID:32715474
Mpomultiple interactionsISOMPO (Homo sapiens)6480464CTD[Melatonin co-treated with coenzyme Q10 co-treated with vinpocetine] inhibits the reaction [Chlorpyrifos results in increased activity of MPO protein]; coenzyme Q10 inhibits the reaction [Chlorpyrifos results in increased activity of MPO protein]; Melatonin inhibits the reaction [Chlorpyrifos results in increased activity of MPO protein]PMID:26519479
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