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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1592081
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mpo
Name: myeloperoxidase
Acc ID: CHEBI:31941
Term: oxaliplatin
Definition: A platinum coordination entity that is a commonly used chemothrepeutic drug for treatment of colorectal cancer.
Chemical ID: MESH:C030110
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mpoincreases activityISOMpo (Mus musculus)6480464CTDoxaliplatin results in increased activity of MPO proteinPMID:24908156
Mpomultiple interactionsISOMpo (Mus musculus)6480464CTDQuercetin inhibits the reaction [oxaliplatin results in increased activity of MPO protein]PMID:24908156
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