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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1592081
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mpo
Name: myeloperoxidase
Acc ID: CHEBI:16240
Term: hydrogen peroxide
Definition: An inorganic peroxide consisting of two hydroxy groups joined by a covalent oxygen-oxygen single bond.
Chemical ID: MESH:D006861
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mpoincreases activityISOMPO (Homo sapiens)6480464CTDHydrogen Peroxide results in increased activity of MPO proteinPMID:28754375
Mpoincreases degradationISOMPO (Homo sapiens)6480464CTDMPO protein results in increased degradation of Hydrogen PeroxidePMID:34085520
Mpoincreases metabolic processingISOMpo (Mus musculus)6480464CTDMPO protein results in increased metabolism of Hydrogen PeroxidePMID:22036979
Mpomultiple interactionsISOMpo (Mus musculus)6480464CTDcaffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [MPO protein results in increased metabolism of Hydrogen Peroxide]]; Tetradecanoylphorbol Acetate promotes the reaction [MPO protein results in increased metabolism of Hydrogen Peroxide]PMID:22036979
Mpomultiple interactionsISOMPO (Homo sapiens)6480464CTD4'-hydroxydiclofenac promotes the reaction [[Hydrogen Peroxide co-treated with MPO protein co-treated with Glutathione] results in increased glutathionylation of 5,5-dimethyl-1-pyrroline-1-oxide]; 4'-hydroxydiclofenac promotes the reaction [Hydrogen Peroxide results in increased activity of MPO protein]; 4-amino-TEMPO inhibits the reaction [MPO protein results in increased degradation of Hydrogen Peroxide]; [1,6-diaminohexane binds to TEMPO] inhibits the reaction [MPO protein results in increased degradation of Hydrogen Peroxide]; [[[MPO protein co-treated with Hydrogen Peroxide] results in increased metabolism of hydroquinone] which results in increased chemical synthesis of quinone] which results in decreased activity of PTPN2 protein; [[Hydrogen Peroxide results in increased activity of MPO protein] which results in increased oxidation of Glutathione] which results in increased glutathionylation of 5,5-dimethyl-1-pyrroline-1-oxide; [[MPO protein co-treated with Chlorides co-treated with Threonine co-treated with Hydrogen Peroxide] results in increased chemical synthesis of Acrolein] which results in increased phosphorylation of AKT1 protein; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2,4-dichloroaniline] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2,4-xylidine] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2,6-xylidine] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2-anisidine] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2-chloroaniline] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2-toluidine] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 3,4-dichloroaniline] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 3,4-xylidine] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 3-anisidine] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 3-chloroaniline] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 3-toluidine] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 4-aminobenzonitrile] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 4-chloroaniline] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 4-ethylaniline] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 4-fluoroaniline] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 4-nitroaniline] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 4-toluidine] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of Aminoglutethimide] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of aniline] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of Procainamide] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with Sodium Chloride] results in increased oxidation of APOA1 protein] which results in decreased activity of LCAT protein; [[MPO protein co-treated with Hydrogen Peroxide] results in increased metabolism of hydroquinone] which results in increased chemical synthesis of quinone; [[MPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of nimesulide metabolite] which results in increased chemical synthesis of nimesulide metabolite; [[MPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Sulfamethoxazole] which results in increased chemical synthesis of 4-nitrososulfamethoxazole; [Aminoglutethimide co-treated with Hydrogen Peroxide] results in increased oxidation of MPO protein; [Cadaverine binds to TEMPO] inhibits the reaction [MPO protein results in increased degradation of Hydrogen Peroxide]; [ethylenediamine binds to TEMPO] inhibits the reaction [MPO protein results in increased degradation of Hydrogen Peroxide]; [Hydrogen Peroxide co-treated with MPO protein co-treated with Glutathione] results in increased glutathionylation of 5,5-dimethyl-1-pyrroline-1-oxide; [Hydrogen Peroxide results in increased activity of MPO protein] which results in increased oxidation of and results in increased susceptibility to 4'-hydroxydiclofenac; [Hydrogen Peroxide results in increased activity of MPO protein] which results in increased oxidation of and results in increased susceptibility to 5-hydroxydiclofenac; [Hydrogen Peroxide results in increased activity of MPO protein] which results in increased oxidation of and results in increased susceptibility to 5-hydroxyindomethacin; [Hydrogen Peroxide results in increased activity of MPO protein] which results in increased oxidation of and results in increased susceptibility to desmethylnaproxen; [Hydrogen Peroxide results in increased activity of MPO protein] which results in increased oxidation of and results in increased susceptibility to Diclofenac; [Hydrogen Peroxide results in increased activity of MPO protein] which results in increased oxidation of and results in increased susceptibility to Indomethacin metabolite; [Hydrogen Peroxide results in increased activity of MPO protein] which results in increased oxidation of and results in increased susceptibility to Naproxen; [Hydrogen Peroxide results in increased activity of MPO protein] which results in increased oxidation of Glutathione; [MPO protein co-treated with Chlorides co-treated with Threonine co-treated with Hydrogen Peroxide] results in increased chemical synthesis of Acrolein; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2,4-dichloroaniline; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2,4-xylidine; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2,6-xylidine; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2-anisidine; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2-chloroaniline; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2-toluidine; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 3,4-dichloroaniline; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 3,4-xylidine; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 3-anisidine; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 3-chloroaniline; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 3-toluidine; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 4-aminobenzonitrile; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 4-chloroaniline; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 4-ethylaniline; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 4-fluoroaniline; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 4-nitroaniline; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 4-toluidine; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of Aminoglutethimide; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of aniline; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of Procainamide; [MPO protein co-treated with Hydrogen Peroxide co-treated with Sodium Chloride] results in increased oxidation of APOA1 protein; [MPO protein co-treated with Hydrogen Peroxide] promotes the reaction [hydroquinone results in decreased activity of TOP2A protein]; [MPO protein co-treated with Hydrogen Peroxide] results in increased metabolism of hydroquinone; [MPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Albuterol; [MPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of and affects the activity of nimesulide metabolite; [MPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Fenoterol; [MPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Sulfamethoxazole; [MPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Terbutaline; [Putrescine binds to TEMPO] inhibits the reaction [MPO protein results in increased degradation of Hydrogen Peroxide]; [Spermine binds to TEMPO] inhibits the reaction [MPO protein results in increased degradation of Hydrogen Peroxide]; [trimethylenediamine binds to TEMPO] inhibits the reaction [MPO protein results in increased degradation of Hydrogen Peroxide]; Ascorbic Acid inhibits the reaction [[MPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Albuterol]; Ascorbic Acid inhibits the reaction [[MPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Fenoterol]; CAT protein inhibits the reaction [[MPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Albuterol]; CAT protein inhibits the reaction [[MPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Fenoterol]; desmethylnaproxen promotes the reaction [[Hydrogen Peroxide co-treated with MPO protein co-treated with Glutathione] results in increased glutathionylation of 5,5-dimethyl-1-pyrroline-1-oxide]; desmethylnaproxen promotes the reaction [Hydrogen Peroxide results in increased activity of MPO protein]; Glutathione inhibits the reaction [[MPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Albuterol]; Glutathione inhibits the reaction [[MPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Fenoterol]; Hydrogen Peroxide promotes the reaction [[MPO protein results in increased oxidation of dibromoacetonitrile] which results in increased chemical synthesis of Cyanides]; Hydrogen Peroxide promotes the reaction [MPO protein results in increased oxidation of dibromoacetonitrile]; MitoTEMPO inhibits the reaction [MPO protein results in increased degradation of Hydrogen Peroxide]; resorcinol inhibits the reaction [[[MPO protein co-treated with Chlorides co-treated with Threonine co-treated with Hydrogen Peroxide] results in increased chemical synthesis of Acrolein] which results in increased phosphorylation of AKT1 protein]; Sodium Azide inhibits the reaction [[MPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Albuterol]; Sodium Azide inhibits the reaction [[MPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Fenoterol]; Sodium Cyanide inhibits the reaction [[MPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Albuterol]; Sodium Cyanide inhibits the reaction [[MPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Fenoterol]; tempo carboxylic acid inhibits the reaction [MPO protein results in increased degradation of Hydrogen Peroxide]; TEMPOL-H inhibits the reaction [MPO protein results in increased degradation of Hydrogen Peroxide]; Wortmannin inhibits the reaction [[[MPO protein co-treated with Chlorides co-treated with Threonine co-treated with Hydrogen Peroxide] results in increased chemical synthesis of Acrolein] which results in increased phosphorylation of AKT1 protein]PMID:15935818 PMID:19462961 PMID:20199096 PMID:20939553 PMID:25531135 PMID:25614581 PMID:26102013 PMID:26262998 PMID:28754375 PMID:31248982 PMID:33861588 PMID:34085520
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