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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1559721
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ifi27l2a
Name: interferon, alpha-inducible protein 27 like 2A
Acc ID: CHEBI:46345
Term: 5-fluorouracil
Definition: A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Chemical ID: MESH:D005472
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ifi27l2amultiple interactionsISOIFI27L2 (Homo sapiens)6480464CTD[Fluorouracil co-treated with irinotecan] results in increased expression of IFI27L2 mRNAPMID:16391804
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