Ifi27l2b (interferon, alpha-inducible protein 27 like 2B) - Rat Genome Database

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Gene: Ifi27l2b (interferon, alpha-inducible protein 27 like 2B) Rattus norvegicus
Analyze
Symbol: Ifi27l2b
Name: interferon, alpha-inducible protein 27 like 2B
RGD ID: 1559721
Description: Predicted to be involved in apoptotic signaling pathway. Predicted to act upstream of or within response to virus. Predicted to be located in mitochondrial membrane. Predicted to be active in mitochondrion. Orthologous to human IFI27L2 (interferon alpha inducible protein 27 like 2); INTERACTS WITH 17alpha-ethynylestradiol; bromobenzene; piperonyl butoxide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: interferon alpha-inducible protein 27-like protein 2B; isg12(b); ISG12(b) protein-like; putative ISG12(b) protein
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86128,363,658 - 128,365,144 (-)NCBIGRCr8
mRatBN7.26122,598,872 - 122,600,358 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6122,598,872 - 122,600,360 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6122,739,795 - 122,741,281 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06123,035,057 - 123,036,543 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06122,369,700 - 122,371,186 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06127,336,305 - 127,337,791 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6127,336,305 - 127,337,791 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06136,556,836 - 136,558,322 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46127,733,540 - 127,735,026 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera6120,079,561 - 120,081,047 (-)NCBICelera
Cytogenetic Map6q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12388728   PMID:12477932   PMID:14728724   PMID:27673746  


Genomics

Comparative Map Data
Ifi27l2b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86128,363,658 - 128,365,144 (-)NCBIGRCr8
mRatBN7.26122,598,872 - 122,600,358 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6122,598,872 - 122,600,360 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6122,739,795 - 122,741,281 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06123,035,057 - 123,036,543 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06122,369,700 - 122,371,186 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06127,336,305 - 127,337,791 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6127,336,305 - 127,337,791 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06136,556,836 - 136,558,322 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46127,733,540 - 127,735,026 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera6120,079,561 - 120,081,047 (-)NCBICelera
Cytogenetic Map6q32NCBI
IFI27L2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381494,127,781 - 94,129,604 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1494,127,779 - 94,130,253 (-)EnsemblGRCh38hg38GRCh38
GRCh371494,594,118 - 94,595,941 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361493,663,871 - 93,665,710 (-)NCBINCBI36Build 36hg18NCBI36
Build 341493,663,870 - 93,665,710NCBI
Celera1474,647,895 - 74,649,734 (-)NCBICelera
Cytogenetic Map14q32.12NCBI
HuRef1474,773,932 - 74,775,771 (-)NCBIHuRef
CHM1_11494,532,109 - 94,533,948 (-)NCBICHM1_1
T2T-CHM13v2.01488,355,089 - 88,356,912 (-)NCBIT2T-CHM13v2.0
Ifi27l2a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912103,400,132 - 103,409,939 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12103,408,426 - 103,409,939 (-)EnsemblGRCm39 Ensembl
GRCm3812103,433,873 - 103,443,680 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12103,442,167 - 103,443,680 (-)EnsemblGRCm38mm10GRCm38
MGSCv3712104,680,377 - 104,681,890 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612103,843,217 - 103,844,709 (-)NCBIMGSCv36mm8
Celera12104,658,928 - 104,660,441 (-)NCBICelera
Cytogenetic Map12ENCBI
cM Map1252.93NCBI
IFI27L2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21595,285,103 - 95,287,214 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11494,501,608 - 94,503,587 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01474,759,874 - 74,761,850 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11494,093,082 - 94,095,062 (-)NCBIpanpan1.1PanPan1.1panPan2
IFI27L2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1863,163,396 - 63,166,045 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha862,740,750 - 62,742,629 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0863,435,185 - 63,437,059 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1863,112,673 - 63,114,545 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0863,164,172 - 63,166,033 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0863,494,431 - 63,496,305 (-)NCBIUU_Cfam_GSD_1.0
Ifi27l2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864011,500,851 - 11,502,498 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367331,961,616 - 1,966,265 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367331,964,545 - 1,966,157 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ISG12(A)
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7115,356,517 - 115,361,538 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.17115,356,619 - 115,361,537 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27122,215,592 - 122,220,522 (+)NCBISscrofa10.2Sscrofa10.2susScr3
IFI27L2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12471,901,911 - 71,903,794 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2471,901,852 - 71,903,831 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605359,139,440 - 59,141,359 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:41
Count of miRNA genes:39
Interacting mature miRNAs:41
Transcripts:ENSRNOT00000032015
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)672202632130729475Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)672202632130919985Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)672227641130729205Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)672227641130729205Rat
738034Anxrr5Anxiety related response QTL 55.9exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)684130881129130881Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)685140138130140138Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)685140138130140138Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)685311061133478515Rat
1300076Glom8Glomerulus QTL 870.000000009kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)686894788131894788Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)688047916133047916Rat
1331725Bp212Blood pressure QTL 2123.52475arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)693701310128713626Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)694968928137848904Rat
12801411Schws8Schwannoma susceptibility QTL 8nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)694968928139968928Rat
8552796Vie3Viral induced encephalitis QTL 32.6brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)696833997140994061Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6100364669140994061Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6100671796132340886Rat
1331797Bp213Blood pressure QTL 2133.291arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)6104085867128713626Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6105156861140994061Rat
4145118Mcs26Mammary carcinoma susceptibility QTL 260.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6106752656132339866Rat
737976Pia24Pristane induced arthritis QTL 24joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)6112636280140994061Rat
1298087Iddm18Insulin dependent diabetes mellitus QTL 180.0001urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)6116506292130245370Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)6122549046137801795Rat
2293085Iddm29Insulin dependent diabetes mellitus QTL 297.66blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)6122549046140286318Rat
61329Eae9Experimental allergic encephalomyelitis QTL 93.7body mass (VT:0001259)change in body weight (CMO:0002045)6122549046140994061Rat

Markers in Region
RH127563  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26122,598,880 - 122,599,072 (+)MAPPERmRatBN7.2
Rnor_6.06127,336,314 - 127,336,505NCBIRnor6.0
Rnor_5.06136,556,845 - 136,557,036UniSTSRnor5.0
RGSC_v3.46127,733,549 - 127,733,740UniSTSRGSC3.4
Celera6120,079,570 - 120,079,761UniSTS
RH 3.4 Map6835.89UniSTS
Cytogenetic Map6q32UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 15 57 41 19 41 7 8 12 19 11 7
Low 28 1 3 70 23 22 1
Below cutoff 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000032015   ⟹   ENSRNOP00000035385
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6122,598,872 - 122,600,360 (-)Ensembl
Rnor_6.0 Ensembl6127,336,305 - 127,337,791 (-)Ensembl
RefSeq Acc Id: NM_206846   ⟹   NP_996728
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86128,363,658 - 128,365,144 (-)NCBI
mRatBN7.26122,598,872 - 122,600,358 (-)NCBI
Rnor_6.06127,336,305 - 127,337,791 (-)NCBI
Rnor_5.06136,556,836 - 136,558,322 (-)NCBI
RGSC_v3.46127,733,540 - 127,735,026 (-)RGD
Celera6120,079,561 - 120,081,047 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_996728 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI66870 (Get FASTA)   NCBI Sequence Viewer  
  CAE00407 (Get FASTA)   NCBI Sequence Viewer  
  EDL81779 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000035385
  ENSRNOP00000035385.6
Reference Protein Sequences
RefSeq Acc Id: NP_996728   ⟸   NM_206846
- UniProtKB: Q6IEA8 (UniProtKB/TrEMBL),   F7FIE2 (UniProtKB/TrEMBL),   B2RYR1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000035385   ⟸   ENSRNOT00000032015

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6IEA8-F1-model_v2 AlphaFold Q6IEA8 1-95 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694795
Promoter ID:EPDNEW_R5319
Type:multiple initiation site
Name:Ifi27l2b_1
Description:interferon, alpha-inducible protein 27 like 2B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.06127,337,791 - 127,337,851EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1559721 AgrOrtholog
BioCyc Gene G2FUF-36412 BioCyc
Ensembl Genes ENSRNOG00000026605 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000032015 ENTREZGENE
  ENSRNOT00000032015.6 UniProtKB/TrEMBL
Gene3D-CATH 6.10.110.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:6922110 IMAGE-MGC_LOAD
InterPro IFI6/IFI27-like_sf UniProtKB/TrEMBL
  Interferon-induced_6-16 UniProtKB/TrEMBL
KEGG Report rno:299269 UniProtKB/TrEMBL
MGC_CLONE MGC:188792 IMAGE-MGC_LOAD
NCBI Gene 299269 ENTREZGENE
PANTHER Ifi-6-16 UniProtKB/TrEMBL
  INTERFERON ALPHA-INDUCIBLE PROTEIN 27, MITOCHONDRIAL UniProtKB/TrEMBL
Pfam Ifi-6-16 UniProtKB/TrEMBL
PhenoGen Ifi27l2b PhenoGen
RatGTEx ENSRNOG00000026605 RatGTEx
UniProt B2RYR1 ENTREZGENE, UniProtKB/TrEMBL
  F7FIE2 ENTREZGENE
  Q6IEA8 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary F7FIE2 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-02-18 Ifi27l2b  interferon, alpha-inducible protein 27 like 2B  isg12(b)  putative ISG12(b) protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-02-09 isg12(b)  putative ISG12(b) protein      Symbol and Name status set to provisional 70820 PROVISIONAL