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GENE - TERM ANNOTATION REPORT

RGD ID: 1558435
Species: Mus musculus
RGD Object: Gene
Symbol: Mapk8ip3
Name: mitogen-activated protein kinase 8 interacting protein 3
Acc ID: GO:0005078
Term: MAP-kinase scaffold activity
Definition: The binding activity of a molecule that functions as a physical support for the assembly of a multiprotein mitogen-activated protein kinase (MAPK) complex. Binds multiple kinases of the MAPKKK cascade, and also upstream signaling proteins, permitting those molecules to function in a coordinated way. Bringing together multiple enzymes and their substrates enables the signal to be transduced quickly and efficiently.
Definition Source(s): PMID:12511654, PMID:15213240, PMID:9405336
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk8ip3enablesIDA 2290270BHF-UCL MGI:1890011 PMID:10523642

MGI:1890011 PMID:10523642
Mapk8ip3enablesIBAPANTHER:PTN001015989 or WB:WBGene00006755 or MGI:1918084 or MGI:13535982290270GO_Central GO_REF:0000033
Mapk8ip3enablesIPIUniProtKB:Q91Y862290270UniProt MGI:1352260 PMID:10629060

MGI:1352260 PMID:10629060
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