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GENE - TERM ANNOTATION REPORT

RGD ID: 1558139
Species: Mus musculus
RGD Object: Gene
Symbol: Dkk2
Name: dickkopf WNT signaling pathway inhibitor 2
Acc ID: GO:0090090
Term: negative regulation of canonical Wnt signaling pathway
Definition: Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
Definition Source(s): GOC:dph, GOC:tb
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dkk2involved_inIBAPANTHER:PTN001383489 or UniProtKB:Q9UBU2 or UniProtKB:O94907 or UniProtKB:Q9UBP4 or MGI:1329040 or ZFIN:ZDB-GENE-990708-52290270GO_Central GO_REF:0000033
Dkk2involved_inISOUniProtKB:Q9UBU22290270MGI GO_REF:0000119 MGI:4834177
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