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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1557033
Species: Mus musculus
RGD Object: Gene
Symbol: Fundc1
Name: FUN14 domain containing 1
Acc ID: CHEBI:28201
Term: rotenone
Definition: A member of the class of rotenones that consists of 1,2,12,12a-tetrahydrochromeno[3,4-b]furo[2,3-h]chromen-6(6aH)-one substituted at position 2 by a prop-1-en-2-yl group and at positions 8 and 9 by methoxy groups (the 2R,6aS,12aS-isomer). A non-systemic insecticide, it is the principal insecticidal constituent of derris (the dried rhizome and root of Derris elliptica).
Chemical ID: MESH:D012402
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fundc1decreases expressionISOFUNDC1 (Homo sapiens)6480464CTDRotenone results in decreased expression of FUNDC1 proteinPMID:32001317 PMID:37156403
Fundc1multiple interactionsISOFUNDC1 (Homo sapiens)6480464CTD[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Rotenone] results in increased expression of FUNDC1 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Rotenone results in decreased expression of FUNDC1 protein]; Chloroquine inhibits the reaction [Rotenone results in decreased expression of FUNDC1 protein]; CSNK2A1 protein affects the reaction [Rotenone results in decreased expression of FUNDC1 protein]; FUNDC1 protein affects the reaction [Rotenone results in increased cleavage of CASP3 protein]PMID:32001317 PMID:37156403
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