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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1552151
Species: Mus musculus
RGD Object: Gene
Symbol: Dnmt1
Name: DNA methyltransferase 1
Acc ID: CHEBI:17230
Term: homocysteine
Definition: A sulfur-containing amino acid consisting of a glycine core with a 2-mercaptoethyl side-chain.
Chemical ID: MESH:D006710
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dnmt1decreases activityISODNMT1 (Homo sapiens)6480464CTDHomocysteine results in decreased activity of DNMT1 proteinPMID:17698632
Dnmt1multiple interactionsISODNMT1 (Homo sapiens)6480464CTDDNMT1 protein affects the reaction [Homocysteine results in decreased expression of CCNA1 mRNA]PMID:17698632
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