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GENE - TERM ANNOTATION REPORT

RGD ID: 13886405
Species: Sus scrofa
RGD Object: Gene
Symbol: FZD4
Name: frizzled class receptor 4
Acc ID: GO:0060070
Term: canonical Wnt signaling pathway
Definition: A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes.
Definition Source(s): PMID:11532397, PMID:19619488
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
FZD4involved_inIEAUniProtKB:Q61088 or UniProtKB:Q9ULV1 or ensembl:ENSMUSP00000049852 or ensembl:ENSP00000434034150520179Ensembl GO_REF:0000107
FZD4acts_upstream_of_or_withinISOMGI:989569068941MGI PMID:16115200

PMID:16115200
FZD4acts_upstream_of_or_withinISOMGI:989629068941MGI PMID:16163358

PMID:16163358
FZD4involved_inIEAPANTHER:PTHR11309:SF23150520179TreeGrafter GO_REF:0000118
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