FZD4 (frizzled class receptor 4) - Rat Genome Database

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Gene: FZD4 (frizzled class receptor 4) Sus scrofa
Analyze
Symbol: FZD4
Name: frizzled class receptor 4
RGD ID: 13886405
Description: ENCODES a protein that exhibits Wnt-protein binding (ortholog); INVOLVED IN angiogenesis (ortholog); blood vessel development (ortholog); canonical Wnt signaling pathway (ortholog); PARTICIPATES IN Wnt signaling pathway; ASSOCIATED WITH Arachnodactyly (ortholog); cleft palate (ortholog); Coats disease (ortholog); FOUND IN glutamatergic synapse (ortholog); synapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: frizzled 4, seven transmembrane spanning receptor; frizzled family receptor 4; frizzled homolog 4; frizzled-4; frizzled-like protein 4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl920,717,344 - 20,721,460 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1920,714,995 - 20,721,460 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2923,000,092 - 23,006,583 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
FZD4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl920,717,344 - 20,721,460 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1920,714,995 - 20,721,460 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2923,000,092 - 23,006,583 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FZD4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381186,945,679 - 86,955,395 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1186,945,679 - 86,955,395 (-)EnsemblGRCh38hg38GRCh38
GRCh371186,656,721 - 86,666,437 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361186,334,369 - 86,344,081 (-)NCBINCBI36Build 36hg18NCBI36
Build 341186,334,369 - 86,344,081NCBI
Celera1183,968,074 - 83,977,786 (-)NCBICelera
Cytogenetic Map11q14.2NCBI
HuRef1182,945,786 - 82,952,580 (-)NCBIHuRef
CHM1_11186,542,809 - 86,552,528 (-)NCBICHM1_1
T2T-CHM13v2.01186,886,525 - 86,896,237 (-)NCBIT2T-CHM13v2.0
Fzd4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39789,053,574 - 89,062,341 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl789,053,563 - 89,062,342 (+)EnsemblGRCm39 Ensembl
GRCm38789,404,366 - 89,410,110 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl789,404,355 - 89,413,134 (+)EnsemblGRCm38mm10GRCm38
MGSCv37796,552,876 - 96,558,620 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36789,279,586 - 89,285,277 (+)NCBIMGSCv36mm8
Celera786,759,990 - 86,765,732 (+)NCBICelera
Cytogenetic Map7D3NCBI
cM Map749.32NCBI
Fzd4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81152,692,507 - 152,701,372 (+)NCBIGRCr8
mRatBN7.21143,279,934 - 143,288,799 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1143,280,065 - 143,285,724 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1151,227,346 - 151,236,226 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01158,403,735 - 158,412,613 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01151,277,642 - 151,286,520 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01153,589,471 - 153,598,376 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1153,589,471 - 153,598,375 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01159,893,040 - 159,901,945 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41145,953,743 - 145,957,666 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11146,032,165 - 146,036,072 (+)NCBI
Celera1141,540,910 - 141,549,599 (+)NCBICelera
Cytogenetic Map1q32NCBI
Fzd4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554146,094,585 - 6,098,865 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554146,094,585 - 6,103,910 (+)NCBIChiLan1.0ChiLan1.0
FZD4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2987,865,408 - 87,875,132 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11188,878,954 - 88,926,949 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01181,973,680 - 82,007,733 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11185,606,572 - 85,616,906 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1185,611,989 - 85,616,065 (-)Ensemblpanpan1.1panPan2
FZD4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12112,699,886 - 12,709,132 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2112,699,774 - 12,724,923 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2112,566,451 - 12,575,366 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02112,882,804 - 12,891,736 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2112,882,819 - 12,891,405 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12112,669,287 - 12,678,212 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02112,740,838 - 12,749,754 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02112,797,007 - 12,805,927 (+)NCBIUU_Cfam_GSD_1.0
Fzd4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494773,060,370 - 73,067,275 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649814,662,659 - 14,666,883 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649814,657,641 - 14,666,853 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FZD4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1178,164,243 - 78,199,296 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl178,188,630 - 78,198,187 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604347,525,967 - 47,562,995 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fzd4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248453,046,063 - 3,050,560 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248452,972,308 - 3,055,596 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in FZD4
106 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 1 1 3 2 2 2
Low 9 3 3 2 23 3 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000033976   ⟹   ENSSSCP00000029767
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl920,628,926 - 20,721,766 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000081843   ⟹   ENSSSCP00000059855
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl920,294,885 - 20,721,460 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000084182   ⟹   ENSSSCP00000066658
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl920,717,344 - 20,721,460 (-)Ensembl
RefSeq Acc Id: XM_005667210   ⟹   XP_005667267
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1920,714,995 - 20,721,460 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005667267 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AEB78654 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSSCP00000066658.2
  ENSSSCP00045012581.1
  ENSSSCP00055034416.1
  ENSSSCP00060018091.1
  ENSSSCP00070022487.1
GenBank Protein JAG69532 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_005667267   ⟸   XM_005667210
- UniProtKB: A0A5G2QP37 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000059855   ⟸   ENSSSCT00000081843
RefSeq Acc Id: ENSSSCP00000029767   ⟸   ENSSSCT00000033976
RefSeq Acc Id: ENSSSCP00000066658   ⟸   ENSSSCT00000084182
Protein Domains
FZ   G-protein coupled receptors family 2 profile


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000014920 Ensembl, UniProtKB/TrEMBL
  ENSSSCG00045010752 UniProtKB/TrEMBL
  ENSSSCG00055022062 UniProtKB/TrEMBL
  ENSSSCG00060031389 UniProtKB/TrEMBL
  ENSSSCG00070013854 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000084182.2 UniProtKB/TrEMBL
  ENSSSCT00045018251.1 UniProtKB/TrEMBL
  ENSSSCT00055043257.1 UniProtKB/TrEMBL
  ENSSSCT00060042476.1 UniProtKB/TrEMBL
  ENSSSCT00070027045.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.2000.10 UniProtKB/TrEMBL
  Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro Frizzled/SFRP UniProtKB/TrEMBL
  Frizzled/Smoothened_TM UniProtKB/TrEMBL
  Frizzled_dom UniProtKB/TrEMBL
  Frizzled_dom_sf UniProtKB/TrEMBL
  FZ4_CRD UniProtKB/TrEMBL
  FZD4_TM UniProtKB/TrEMBL
  GPCR_2-like UniProtKB/TrEMBL
KEGG Report ssc:100520319 UniProtKB/TrEMBL
NCBI Gene FZD4 ENTREZGENE
PANTHER PTHR11309 UniProtKB/TrEMBL
  PTHR11309:SF23 UniProtKB/TrEMBL
Pfam Frizzled UniProtKB/TrEMBL
  PF01392 UniProtKB/TrEMBL
PRINTS FRIZZLED UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F2_4 UniProtKB/TrEMBL
  PS50038 UniProtKB/TrEMBL
SMART FRI UniProtKB/TrEMBL
  Frizzled UniProtKB/TrEMBL
Superfamily-SCOP SSF63501 UniProtKB/TrEMBL
UniProt A0A480XCK5_PIG UniProtKB/TrEMBL
  A0A4X1U400_PIG UniProtKB/TrEMBL
  A0A5G2QP37 ENTREZGENE, UniProtKB/TrEMBL
  F4YE00_PIG UniProtKB/TrEMBL
VGNC ID VGNC:88282 ENTREZGENE