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GENE - TERM ANNOTATION REPORT

RGD ID: 13886405
Species: Sus scrofa
RGD Object: Gene
Symbol: FZD4
Name: frizzled class receptor 4
Acc ID: DOID:13025
Term: retinopathy of prematurity
Definition: A bilateral retinopathy occurring in premature infants treated with excessively high concentrations of oxygen, characterized by vascular dilatation, proliferation, and tortuosity, edema, and retinal detachment, with ultimate conversion of the retina into a fibrous mass that can be seen as a dense retrolental membrane. Usually growth of the eye is arrested and may result in microophthalmia, and blindness may occur. (Dorland, 27th ed)
Definition Source(s): MESH:D012178
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
FZD4 ISOFZD4 (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Retinopathy of prematurityPMID:15733276 PMID:25741868 PMID:28492532
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