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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352761
Species: Homo sapiens
RGD Object: Gene
Symbol: RELA
Name: RELA proto-oncogene, NF-kB subunit
Acc ID: CHEBI:73755
Term: 1,2-dimethylhydrazine
Definition: A member of the class of hydrazines that is hydrazine in which one of the hydrogens attached to each nitrogen is replaced by a methyl group. A powerful DNA alkylating agent and carcinogen, it is used to induce colon cancer in laboratory rats and mice.
Chemical ID: MESH:D019813
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
RELAincreases expressionISORela (Mus musculus)6480464CTD1,2-Dimethylhydrazine results in increased expression of RELA mRNAPMID:22206623
RELAincreases expressionISORela (Rattus norvegicus)6480464CTD1,2-Dimethylhydrazine results in increased expression of RELA proteinPMID:30720227 PMID:31925992 PMID:34627785 PMID:35567572
RELAincreases phosphorylationISORela (Rattus norvegicus)6480464CTD1,2-Dimethylhydrazine results in increased phosphorylation of RELA proteinPMID:29879413
RELAmultiple interactionsISORela (Mus musculus)6480464CTD[1,2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of RELA mRNAPMID:22206623
RELAmultiple interactionsISORela (Rattus norvegicus)6480464CTDGallic Acid inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of RELA protein]; hesperetin inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of RELA protein]; p-coumaric acid inhibits the reaction [1,2-Dimethylhydrazine results in increased phosphorylation of RELA protein]; piclamilast inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of RELA protein]; zingerone inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of RELA protein]PMID:29879413 PMID:30720227 PMID:31925992 PMID:34627785 PMID:35567572
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