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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352469
Species: Homo sapiens
RGD Object: Gene
Symbol: NR1H2
Name: nuclear receptor subfamily 1 group H member 2
Acc ID: CHEBI:16113
Term: cholesterol
Definition: A cholestanoid consisting of cholestane having a double bond at the 5,6-position as well as a 3beta-hydroxy group.
Chemical ID: MESH:D002784
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NR1H2increases activityEXP 6480464CTDCholesterol results in increased activity of NR1H2 proteinPMID:21543282
NR1H2multiple interactionsISONr1h2 (Mus musculus)6480464CTD[RXRB protein binds to NR1H2 protein] which affects the metabolism of Cholesterol; NR1H2 gene mutant form inhibits the reaction [pitavastatin inhibits the reaction [8-((4-chlorophenyl)thio)cyclic-3',5'-AMP results in increased export of Cholesterol]]; NR1H2 gene mutant form inhibits the reaction [pitavastatin results in decreased export of Cholesterol]PMID:14993927 PMID:16415093
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