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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1345007
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP2E1
Name: cytochrome P450 family 2 subfamily E member 1
Acc ID: CHEBI:16236
Term: ethanol
Definition: A primary alcohol that is ethane in which one of the hydrogens is substituted by a hydroxy group.
Chemical ID: MESH:D000431
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP2E1affects activityEXP 6480464CTDEthanol affects the activity of CYP2E1 proteinPMID:22530035
CYP2E1affects response to substanceEXP 6480464CTDCYP2E1 gene polymorphism affects the susceptibility to Ethanol; CYP2E1 protein affects the susceptibility to EthanolPMID:20171022 PMID:33017621
CYP2E1increases activityEXP 6480464CTDEthanol results in increased activity of CYP2E1 proteinPMID:11212141 PMID:30380359 PMID:8074729
CYP2E1increases expressionEXP 6480464CTDEthanol results in increased expression of CYP2E1; Ethanol results in increased expression of CYP2E1 mRNA; Ethanol results in increased expression of CYP2E1 proteinPMID:17590308 PMID:19778255 PMID:21352821 PMID:22138249 PMID:23300006 PMID:27794450 PMID:28062356 PMID:28385499 PMID:29362861 PMID:30373287 PMID:30567741 PMID:32283135 PMID:35301062 PMID:35713687 PMID:36372259 PMID:3782137 PMID:8074729
CYP2E1increases metabolic processingEXP 6480464CTDCYP2E1 protein results in increased metabolism of EthanolPMID:10573527 PMID:10826103 PMID:12464242 PMID:18845238 PMID:22530035
CYP2E1increases response to substanceEXP 6480464CTDCYP2E1 protein results in increased susceptibility to EthanolPMID:8798623
CYP2E1increases stabilityEXP 6480464CTDEthanol results in increased stability of CYP2E1 proteinPMID:32199159
CYP2E1multiple interactionsEXP 6480464CTD2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine promotes the reaction [Ethanol results in increased expression of CYP2E1 mRNA]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Ethanol results in increased expression of CYP2E1 mRNA]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Ethanol results in increased expression of CYP2E1 protein]; [[Arachidonic Acid co-treated with ferric nitrilotriacetate co-treated with Ethanol] results in increased expression of CYP2E1 protein] which results in increased expression of KRT18 protein; [[Arachidonic Acid co-treated with ferric nitrilotriacetate co-treated with Ethanol] results in increased expression of CYP2E1 protein] which results in increased expression of KRT8 protein; [[Ethanol affects the activity of CYP2E1 protein] which affects the localization of NFE2L2 protein] which results in increased expression of CYP2A6; [Arachidonic Acid co-treated with ferric nitrilotriacetate co-treated with Ethanol] results in increased expression of CYP2E1 protein; [CYP2E1 protein affects the susceptibility to Ethanol] which affects the expression of ACSL4 protein; [CYP2E1 protein affects the susceptibility to Ethanol] which affects the expression of FXN protein; [CYP2E1 protein affects the susceptibility to Ethanol] which affects the expression of GPX4 protein; [CYP2E1 protein affects the susceptibility to Ethanol] which affects the expression of SLC7A11 protein; [CYP2E1 protein affects the susceptibility to Ethanol] which affects the expression of VDAC2 protein; [CYP2E1 protein results in increased metabolism of Ethanol] promotes the reaction [Ethanol results in increased expression of CYP2A6]; [CYP2E1 protein results in increased metabolism of Ethanol] which results in decreased abundance of Glutathione; [CYP2E1 protein results in increased metabolism of Ethanol] which results in increased abundance of Acetaldehyde; [CYP2E1 protein results in increased metabolism of Ethanol] which results in increased abundance of Nitric Oxide; [CYP2E1 protein results in increased metabolism of Ethanol] which results in increased abundance of Reactive Oxygen Species; [Ethanol affects the activity of CYP2E1 protein] which affects the localization of NFE2L2 protein; [Ethanol co-treated with CYP2E1 protein] results in increased abundance of Reactive Oxygen Species; [Ethanol co-treated with CYP2E1 protein] results in increased phosphorylation of EGFR protein; [Plant Extracts results in increased abundance of Polyphenols] inhibits the reaction [Ethanol results in increased expression of CYP2E1 protein]; Acetylcysteine inhibits the reaction [Ethanol results in increased expression of CYP2E1 mRNA]; allyl sulfide inhibits the reaction [Ethanol results in increased expression of CYP2E1 protein]; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone affects the reaction [FXN protein affects the reaction [CYP2E1 protein affects the susceptibility to Ethanol]]; Betaine promotes the reaction [Ethanol results in increased expression of CYP2E1]; Catechin inhibits the reaction [Ethanol results in increased expression of CYP2E1]; Corticosterone promotes the reaction [Ethanol results in increased expression of CYP2E1 mRNA]; CYP2E1 protein affects the reaction [Ethanol affects the expression of FXN protein]; CYP2E1 protein affects the reaction [Ethanol results in decreased expression of DBN1 mRNA]; CYP2E1 protein affects the reaction [Ethanol results in decreased expression of PPARA mRNA]; CYP2E1 protein affects the reaction [Ethanol results in decreased expression of SYP mRNA]; CYP2E1 protein promotes the reaction [Ethanol results in decreased phosphorylation of MAPK1 protein]; CYP2E1 protein promotes the reaction [Ethanol results in decreased phosphorylation of MAPK3 protein]; CYP2E1 protein promotes the reaction [Ethanol results in increased expression of GCLC mRNA]; diallyl disulfide inhibits the reaction [Ethanol results in increased expression of and results in increased activity of CYP2E1 protein]; erastin affects the reaction [CYP2E1 protein affects the susceptibility to Ethanol]; Ethanol affects the reaction [CYP2E1 protein results in increased metabolism of Dimethylnitrosamine]; Ethanol affects the reaction [CYP2E1 protein results in increased susceptibility to Acetaminophen]; Ethanol inhibits the reaction [Carbon Tetrachloride inhibits the reaction [CYP2E1 protein results in increased oxidation of 4-nitrophenol]]; Ethanol inhibits the reaction [Cycloheximide results in increased degradation of CYP2E1 protein]; Ethanol inhibits the reaction [CYP2E1 protein results in decreased phosphorylation of MAPK1 protein]; Ethanol inhibits the reaction [CYP2E1 protein results in decreased phosphorylation of MAPK3 protein]; Ethanol promotes the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP2E1 mRNA]; Ethanol promotes the reaction [CYP2E1 protein results in increased oxidation of 4-nitrophenol]; Ethanol promotes the reaction [CYP2E1 protein results in increased oxidation of aniline]; Ethanol promotes the reaction [CYP2E1 protein results in increased oxidation of Dimethylnitrosamine]; Ethanol results in increased expression of and results in increased activity of CYP2E1 protein; ferrostatin-1 affects the reaction [CYP2E1 protein affects the susceptibility to Ethanol]; Fomepizole inhibits the reaction [[CYP2E1 protein results in increased metabolism of Ethanol] which results in increased abundance of Reactive Oxygen Species]; FXN protein affects the reaction [[CYP2E1 protein affects the susceptibility to Ethanol] which affects the expression of ACSL4 protein]; FXN protein affects the reaction [[CYP2E1 protein affects the susceptibility to Ethanol] which affects the expression of GPX4 protein]; FXN protein affects the reaction [[CYP2E1 protein affects the susceptibility to Ethanol] which affects the expression of SLC7A11 protein]; FXN protein affects the reaction [[CYP2E1 protein affects the susceptibility to Ethanol] which affects the expression of VDAC2 protein]; FXN protein affects the reaction [CYP2E1 protein affects the susceptibility to Ethanol]; FXN protein affects the reaction [ferrostatin-1 affects the reaction [CYP2E1 protein affects the susceptibility to Ethanol]]; HECTD4 protein promotes the reaction [Ethanol results in increased expression of CYP2E1 mRNA]; Hemin inhibits the reaction [Ethanol results in increased expression of and results in increased activity of CYP2E1 protein]; PPP2CA protein affects the reaction [Ethanol results in increased expression of CYP2E1 protein]; PPP2R5A protein affects the reaction [Ethanol results in increased expression of CYP2E1 mRNA]; PPP2R5A protein affects the reaction [Ethanol results in increased expression of CYP2E1 protein]; Quercetin inhibits the reaction [Ethanol results in increased expression of and results in increased activity of CYP2E1 protein]; Silymarin inhibits the reaction [Ethanol results in increased expression of CYP2E1 protein]; Sirolimus affects the reaction [FXN protein affects the reaction [CYP2E1 protein affects the susceptibility to Ethanol]]; Tetradecanoylphorbol Acetate promotes the reaction [CYP2E1 protein results in increased susceptibility to Ethanol]; tricarbonyldichlororuthenium (II) dimer inhibits the reaction [Ethanol results in increased activity of CYP2E1 protein]; U 0126 inhibits the reaction [Ethanol results in increased expression of CYP2E1 mRNA]; U 0126 inhibits the reaction [Ethanol results in increased expression of CYP2E1 protein]; zinc protoporphyrin inhibits the reaction [Quercetin inhibits the reaction [Ethanol results in increased expression of and results in increased activity of CYP2E1 protein]]; zinc protoporphyrin inhibits the reaction [tricarbonyldichlororuthenium (II) dimer inhibits the reaction [Ethanol results in increased activity of CYP2E1 protein]]PMID:10573527 PMID:11212141 PMID:15802389 PMID:16235733 PMID:17034788 PMID:18845238 PMID:19133322 PMID:19325051 PMID:19778255 PMID:21352821 PMID:22138249 PMID:22222162 PMID:22530035 PMID:22552773 PMID:28385499 PMID:29362861 PMID:30567741 PMID:32237978 PMID:33017621 PMID:35301062 PMID:35713687 PMID:8074729 PMID:8531136 PMID:8798623 PMID:9143349
CYP2E1affects activityISOCyp2e1 (Rattus norvegicus)6480464CTDEthanol affects the activity of CYP2E1 proteinPMID:17533807
CYP2E1decreases activityISOCyp2e1 (Rattus norvegicus)6480464CTDEthanol results in decreased activity of CYP2E1 proteinPMID:17299812
CYP2E1decreases expressionISOCyp2e1 (Mus musculus)6480464CTDEthanol results in decreased expression of CYP2E1 mRNAPMID:28119953
CYP2E1increases activityISOCyp2e1 (Mus musculus)6480464CTDEthanol results in increased activity of CYP2E1 proteinPMID:10667633 PMID:15920153
CYP2E1increases activityISOCyp2e1 (Rattus norvegicus)6480464CTDEthanol results in increased activity of CYP2E1 proteinPMID:15998439 PMID:20116195 PMID:21704112 PMID:22525864 PMID:28442378
CYP2E1increases expressionISOCyp2e1 (Mus musculus)6480464CTDEthanol results in increased expression of CYP2E1; Ethanol results in increased expression of CYP2E1 mRNA; Ethanol results in increased expression of CYP2E1 proteinPMID:11515535 PMID:15920153 PMID:16317704 PMID:19063909 PMID:19951287 PMID:20118189 PMID:22138249 PMID:24946281 PMID:25455889 PMID:25460735 PMID:26769846 PMID:26858005 PMID:28119953 PMID:28419832 PMID:30664321 PMID:32171850 PMID:32237978 PMID:34995708 PMID:35526736 PMID:37271273
CYP2E1increases expressionISOCyp2e1 (Rattus norvegicus)6480464CTDEthanol results in increased expression of CYP2E1 mRNA; Ethanol results in increased expression of CYP2E1 proteinPMID:19609968 PMID:21999510 PMID:22486562 PMID:22960445 PMID:23273579 PMID:23819932 PMID:26747958 PMID:26854922 PMID:27989594 PMID:28385499 PMID:3113478 PMID:32151596 PMID:3416296 PMID:35301062 PMID:36085217 PMID:3782137 PMID:7562599 PMID:7587954 PMID:7601153 PMID:8130774 PMID:9884160
CYP2E1increases metabolic processingISOCyp2e1 (Rattus norvegicus)6480464CTDCYP2E1 protein results in increased metabolism of EthanolPMID:11147839 PMID:15763544 PMID:7562599
CYP2E1increases oxidationISOCyp2e1 (Mus musculus)6480464CTDCYP2E1 protein results in increased oxidation of EthanolPMID:22552773
CYP2E1increases response to substanceISOCyp2e1 (Mus musculus)6480464CTDCYP2E1 protein results in increased susceptibility to EthanolPMID:28131861
CYP2E1increases response to substanceISOCyp2e1 (Rattus norvegicus)6480464CTDCYP2E1 protein results in increased susceptibility to EthanolPMID:21130154
CYP2E1multiple interactionsISOCyp2e1 (Mus musculus)6480464CTD[AQP4 protein affects the susceptibility to Ethanol] which affects the expression of CYP2E1 mRNA; [Betaine co-treated with Choline co-treated with Folic Acid co-treated with Methionine co-treated with Vitamin B 12 co-treated with Zinc Sulfate] inhibits the reaction [Ethanol results in increased expression of CYP2E1 protein]; [Carbon Tetrachloride co-treated with Ethanol] results in decreased expression of CYP2E1 mRNA; [Dietary Fats co-treated with Cholesterol, Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Ethanol] results in increased expression of CYP2E1 mRNA; [Dietary Fats co-treated with Cholesterol, Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Ethanol] results in increased expression of CYP2E1 protein; [ethylene dichloride co-treated with Ethanol] results in increased expression of CYP2E1 mRNA; [ethylene dichloride co-treated with Ethanol] results in increased expression of CYP2E1 protein; [Urethane co-treated with Ethanol] results in increased activity of CYP2E1 protein; [Zinc deficiency co-treated with Ethanol] results in increased expression of CYP2E1 protein; allyl sulfide inhibits the reaction [[ethylene dichloride co-treated with Ethanol] results in increased expression of CYP2E1 protein]; allyl sulfide inhibits the reaction [Ethanol results in increased expression of CYP2E1 protein]; Berberine inhibits the reaction [Ethanol results in increased expression of CYP2E1 protein]; Chlormethiazole inhibits the reaction [Ethanol results in increased activity of CYP2E1 protein]; Chlormethiazole inhibits the reaction [Ethanol results in increased expression of and results in increased activity of CYP2E1 protein]; CYP2E1 protein affects the reaction [Ethanol results in increased expression of and results in increased activity of CYP2A5 protein]; CYP2E1 protein affects the reaction [Ethanol results in increased expression of CYP2A5]; diallyl disulfide inhibits the reaction [Ethanol results in increased expression of CYP2E1 protein]; dihydromyricetin inhibits the reaction [Ethanol results in increased expression of CYP2E1 protein]; dioscin inhibits the reaction [Ethanol results in increased expression of and results in increased activity of CYP2E1 protein]; Ethanol promotes the reaction [ethylene dichloride results in increased expression of CYP2E1 mRNA]; Ethanol promotes the reaction [Fructose results in increased expression of CYP2E1 protein]; Ethanol results in increased expression of and results in increased activity of CYP2E1 protein; ethylene dichloride promotes the reaction [Ethanol results in increased expression of CYP2E1 mRNA]; Plant Extracts inhibits the reaction [Ethanol results in increased expression of and results in increased activity of CYP2E1 protein]; Silymarin inhibits the reaction [Ethanol results in increased expression of and results in increased activity of CYP2E1 protein]; SOD1 protein affects the reaction [Ethanol results in increased expression of CYP2E1 protein]; Zinc Sulfate inhibits the reaction [Ethanol results in increased activity of CYP2E1 protein]; Zinc Sulfate inhibits the reaction [Ethanol results in increased expression of CYP2E1 protein]PMID:15582191 PMID:15920153 PMID:19951287 PMID:20118189 PMID:20615459 PMID:22138249 PMID:22552773 PMID:24146112 PMID:24155903 PMID:24892905 PMID:25455889 PMID:26858005 PMID:28131861 PMID:28419832 PMID:28797650 PMID:30517762 PMID:30664321 PMID:35526736 PMID:37150348 PMID:37271273
CYP2E1multiple interactionsISOCyp2e1 (Rattus norvegicus)6480464CTD[2,4-dichlorophenoxyacetic acid isooctyl ester results in increased abundance of 2,4-Dichlorophenoxyacetic Acid] promotes the reaction [Ethanol results in increased expression of CYP2E1 mRNA]; [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] co-treated with zinc protoporphyrin] results in increased expression of CYP2E1 mRNA; [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] co-treated with zinc protoporphyrin] results in increased expression of CYP2E1 protein; [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased expression of CYP2E1 mRNA; [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased expression of CYP2E1 protein; [CYP2E1 protein results in increased metabolism of Ethanol] which results in increased chemical synthesis of Acetaldehyde; [Ethanol co-treated with nitrosobenzylmethylamine] results in increased expression of CYP2E1 protein; [Ethanol results in increased activity of CYP2E1 protein] which results in increased metabolism of vinyl fluoride; [Oleic Acid co-treated with Palmitic Acid] inhibits the reaction [Ethanol results in increased expression of CYP2E1 mRNA]; allyl sulfide inhibits the reaction [Ethanol results in increased activity of CYP2E1 protein]; Carnitine promotes the reaction [Ethanol results in increased expression of CYP2E1 protein]; dioscin inhibits the reaction [Ethanol results in increased expression of and results in increased activity of CYP2E1 protein]; Ethanol affects the expression of and results in decreased activity of CYP2E1 protein; Ethanol binds to and results in increased expression of CYP2E1 protein; Ethanol inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of CYP2E1 mRNA]; Ethanol inhibits the reaction [CYP2E1 protein results in increased reduction of Tirapazamine]; Ethanol promotes the reaction [[2,4-dichlorophenoxyacetic acid isooctyl ester results in increased abundance of 2,4-Dichlorophenoxyacetic Acid] which results in increased expression of CYP2E1 mRNA]; Ethanol promotes the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of CYP2E1 mRNA]; Ethanol promotes the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of CYP2E1 protein]; Ethanol promotes the reaction [CYP2E1 protein results in increased hydroxylation of aniline]; Ethanol promotes the reaction [CYP2E1 protein results in increased metabolism of 4-nitrophenol]; Ethanol promotes the reaction [CYP2E1 protein results in increased metabolism of Carbon Tetrachloride]; Ethanol promotes the reaction [CYP2E1 protein results in increased oxidation of Toluene]; Ethanol results in increased activity of and results in increased expression of CYP2E1 protein; Ethanol results in increased expression of and results in increased activity of CYP2E1 protein; Genistein inhibits the reaction [Ethanol promotes the reaction [CYP2E1 protein results in increased hydroxylation of aniline]]; Genistein inhibits the reaction [Ethanol results in increased activity of and results in increased expression of CYP2E1 protein]; Hemin inhibits the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased expression of CYP2E1 mRNA]; Hemin inhibits the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased expression of CYP2E1 protein]; Oleanolic Acid inhibits the reaction [Ethanol results in increased expression of and results in increased activity of CYP2E1 protein]; p-coumaric acid inhibits the reaction [Ethanol results in increased expression of CYP2E1 protein]; phenethyl isothiocyanate inhibits the reaction [[CYP2E1 protein results in increased metabolism of Ethanol] which results in increased chemical synthesis of Acetaldehyde]; phenethyl isothiocyanate inhibits the reaction [Ethanol results in increased expression of CYP2E1 mRNA]; phenethyl isothiocyanate inhibits the reaction [Ethanol results in increased expression of CYP2E1 protein]; Plant Extracts inhibits the reaction [Ethanol results in increased activity of CYP2E1 protein]; S-Adenosylmethionine inhibits the reaction [CYP2E1 protein results in increased metabolism of Ethanol]; salvianolic acid B inhibits the reaction [Ethanol results in increased expression of CYP2E1 protein]; zingerone inhibits the reaction [Ethanol results in increased activity of CYP2E1 protein]PMID:15763544 PMID:15946133 PMID:16704527 PMID:19788401 PMID:1994898 PMID:20116195 PMID:21999510 PMID:22525864 PMID:22960445 PMID:23274713 PMID:24146112 PMID:25111957 PMID:26747958 PMID:26854922 PMID:27989594 PMID:28442378 PMID:32151596 PMID:3337723 PMID:35301062 PMID:36085217 PMID:7562599 PMID:7601153 PMID:7710944 PMID:8130774 PMID:9073601
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