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GENE - TERM ANNOTATION REPORT

RGD ID: 1344192
Species: Homo sapiens
RGD Object: Gene
Symbol: TNF
Name: tumor necrosis factor
Acc ID: DOID:9007096
Term: Stroke
Definition: A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)
Definition Source(s): MESH:D020521
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TNFsusceptibilityIAGP 11529997RGDassociated with Anemia, Sickle Cell;DNA:polymorphism:promoter:-308G>A(rs1800629)(human) 
TNF ISOTnf (Rattus norvegicus)4891154RGDmRNA:increased expression:brain 
TNF EXP 11554173CTDCTD Direct Evidence: marker/mechanismPMID:10950380
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