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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1344192
Species: Homo sapiens
RGD Object: Gene
Symbol: TNF
Name: tumor necrosis factor
Acc ID: CHEBI:64243
Term: monosodium L-glutamate
Definition: An optically active form of monosodium glutamate having L-configuration.
Chemical ID: MESH:D012970
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TNFaffects expressionISOTnf (Mus musculus)6480464CTDSodium Glutamate affects the expression of TNF mRNAPMID:18930730
TNFincreases expressionISOTnf (Mus musculus)6480464CTDSodium Glutamate results in increased expression of TNF mRNA; Sodium Glutamate results in increased expression of TNF proteinPMID:19724016 PMID:19800637 PMID:21205225 PMID:27918843 PMID:28708105
TNFmultiple interactionsISOTnf (Mus musculus)6480464CTD[Fats, Unsaturated co-treated with Sodium Glutamate] results in increased expression of TNF protein; [Sodium Glutamate co-treated with Aspartame] promotes the reaction [Fats, Unsaturated results in increased expression of TNF protein]; Atorvastatin inhibits the reaction [Sodium Glutamate results in increased expression of TNF mRNA]; Atorvastatin inhibits the reaction [Sodium Glutamate results in increased expression of TNF protein]; Glycine affects the reaction [Sodium Glutamate affects the expression of TNF mRNA]; Pioglitazone inhibits the reaction [Sodium Glutamate results in increased expression of TNF mRNA]; Plant Extracts inhibits the reaction [Sodium Glutamate results in increased expression of TNF mRNA]; Resveratrol inhibits the reaction [Sodium Glutamate results in increased expression of TNF mRNA]; SRT1720 inhibits the reaction [Sodium Glutamate results in increased expression of TNF mRNA]; SRT1720 inhibits the reaction [Sodium Glutamate results in increased expression of TNF protein]PMID:18930730 PMID:19724016 PMID:19800637 PMID:23783067 PMID:27918843 PMID:28708105
TNFmultiple interactionsISOTnf (Rattus norvegicus)6480464CTD[Fenofibrate co-treated with Sodium Glutamate] results in increased expression of TNF proteinPMID:21999347
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