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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1344192
Species: Homo sapiens
RGD Object: Gene
Symbol: TNF
Name: tumor necrosis factor
Acc ID: CHEBI:46727
Term: quartz
Definition: null
Chemical ID: MESH:D011791
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TNFincreases expressionEXP 6480464CTDQuartz results in increased expression of TNF mRNAPMID:27917503
TNFincreases secretionEXP 6480464CTDQuartz results in increased secretion of TNF proteinPMID:19697923 PMID:29102675 PMID:35499148
TNFmultiple interactionsEXP 6480464CTDATF3 protein affects the reaction [Quartz results in increased secretion of TNF protein]; Quartz results in increased expression of and results in increased secretion of TNF proteinPMID:29102675 PMID:29729927
TNFincreases activityISOTnf (Rattus norvegicus)6480464CTDQuartz results in increased activity of TNF proteinPMID:11306444
TNFincreases expressionISOTnf (Mus musculus)6480464CTDQuartz results in increased expression of TNF mRNAPMID:19298665 PMID:36477571
TNFincreases expressionISOTnf (Rattus norvegicus)6480464CTDQuartz results in increased expression of TNF mRNAPMID:18803060 PMID:19836432
TNFincreases secretionISOTnf (Mus musculus)6480464CTDQuartz results in increased secretion of TNF proteinPMID:19298665 PMID:20085295 PMID:23402729
TNFincreases secretionISOTnf (Rattus norvegicus)6480464CTDQuartz results in increased secretion of TNF proteinPMID:21171611
TNFmultiple interactionsISOTnf (Mus musculus)6480464CTDAscorbic Acid promotes the reaction [Quartz results in increased expression of TNF mRNA]; Ascorbic Acid promotes the reaction [Quartz results in increased secretion of TNF protein]; Butylated Hydroxytoluene inhibits the reaction [Dextran Sulfate promotes the reaction [Ascorbic Acid promotes the reaction [Quartz results in increased secretion of TNF protein]]]; Butylated Hydroxytoluene inhibits the reaction [Dextran Sulfate promotes the reaction [Quartz results in increased secretion of TNF protein]]; CAT protein inhibits the reaction [Ascorbic Acid promotes the reaction [Quartz results in increased secretion of TNF protein]]; CAT protein inhibits the reaction [Quartz results in increased secretion of TNF protein]; Dextran Sulfate promotes the reaction [Ascorbic Acid promotes the reaction [Quartz results in increased secretion of TNF protein]]; Dextran Sulfate promotes the reaction [Quartz results in increased secretion of TNF protein]; IFNG protein promotes the reaction [Ascorbic Acid promotes the reaction [Quartz results in increased secretion of TNF protein]]; IFNG protein promotes the reaction [Quartz results in increased secretion of TNF protein]; Mannitol inhibits the reaction [Ascorbic Acid promotes the reaction [Quartz results in increased secretion of TNF protein]]; Mannitol inhibits the reaction [Quartz results in increased secretion of TNF protein]PMID:19298665
TNFmultiple interactionsISOTnf (Rattus norvegicus)6480464CTDaluminum lactate inhibits the reaction [Quartz results in increased expression of TNF mRNA]PMID:18803060
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