Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	1344192
Species:	Homo sapiens
RGD Object:	Gene
Symbol:	TNF
Name:	tumor necrosis factor

Acc ID:	CHEBI:4356
Term:	desferrioxamine B
Definition:	An acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N(1)-(5-aminopentyl)-N(1)-hydroxy-N(4)-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator.
Chemical ID:	MESH:D003676

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
TNF	decreases activity	EXP		6480464	CTD	Deferoxamine results in decreased activity of TNF protein	PMID:15550384
TNF	decreases expression	EXP		6480464	CTD	Deferoxamine results in decreased expression of TNF mRNA	PMID:9851740
TNF	increases response to substance	EXP		6480464	CTD	Deferoxamine results in increased susceptibility to TNF protein	PMID:16910777
TNF	multiple interactions	EXP		6480464	CTD	[Deferoxamine affects the abundance of Iron] inhibits the reaction [TNF protein results in increased activity of SP1 protein]; [Deferoxamine affects the abundance of Iron] inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; [Deferoxamine affects the abundance of Iron] inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; [Deferoxamine affects the abundance of Iron] inhibits the reaction [TNF protein results in increased expression of SELE mRNA]; [Deferoxamine affects the abundance of Iron] inhibits the reaction [TNF protein results in increased expression of SELE protein]; [Deferoxamine affects the abundance of Iron] inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; [Deferoxamine affects the abundance of Iron] inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; [Deferoxamine co-treated with tert-Butylhydroperoxide] results in increased expression of TNF mRNA; Deferoxamine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Deferoxamine inhibits the reaction [Particulate Matter results in increased expression of TNF mRNA]; ferrous sulfate inhibits the reaction [Deferoxamine results in decreased activity of TNF protein]	PMID:12633744 PMID:15550384 PMID:20801209 PMID:35690295 PMID:9851740
TNF	multiple interactions	ISO	Tnf (Mus musculus)	6480464	CTD	Deferoxamine inhibits the reaction [Asbestos, Crocidolite results in increased secretion of TNF protein]	PMID:10486238
TNF	multiple interactions	ISO	Tnf (Rattus norvegicus)	6480464	CTD	Deferoxamine inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in increased expression of TNF protein]; Deferoxamine inhibits the reaction [Asbestos, Crocidolite results in increased secretion of TNF protein]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Deferoxamine]	PMID:34577062 PMID:7532384 PMID:7539275

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