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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1332312
Species: Mus musculus
RGD Object: Gene
Symbol: Xbp1
Name: X-box binding protein 1
Acc ID: CHEBI:29866
Term: arsenite(3-)
Definition: An arsenite ion resulting from the removal of all three protons from the hydroxy groups of arsenous acid.
Chemical ID: MESH:C015001
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Xbp1increases splicingISOXBP1 (Homo sapiens)6480464CTDarsenite results in increased splicing of XBP1 mRNAPMID:22215663
Xbp1multiple interactionsISOXBP1 (Homo sapiens)6480464CTDarsenite promotes the reaction [G3BP1 protein binds to XBP1 mRNA]; Sirolimus inhibits the reaction [arsenite results in increased splicing of XBP1 mRNA]; SLC38A2 mutant form inhibits the reaction [arsenite results in increased splicing of XBP1 mRNA]PMID:22215663 PMID:32406909
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