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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1332312
Species: Mus musculus
RGD Object: Gene
Symbol: Xbp1
Name: X-box binding protein 1
Acc ID: CHEBI:28393
Term: beta-D-glucosamine
Definition: A 2-amino-2-deoxy-D-glucopyranose that is D-glucosamine having a beta-configuration at the anomeric position.
Chemical ID: MESH:D005944
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Xbp1increases expressionEXP 6480464CTDGlucosamine results in increased expression of XBP1 protein alternative formPMID:30602124
Xbp1increases splicingEXP 6480464CTDGlucosamine results in increased splicing of XBP1 mRNAPMID:30602124
Xbp1multiple interactionsEXP 6480464CTD4-methylumbelliferone 8-carbaldehyde affects the reaction [Glucosamine results in increased expression of XBP1 protein alternative form]; 4-methylumbelliferone 8-carbaldehyde inhibits the reaction [Glucosamine results in increased splicing of XBP1 mRNA]; 4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased expression of XBP1 protein alternative form]; 4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased splicing of XBP1 mRNA]; ERN1 protein affects the reaction [Glucosamine results in increased splicing of XBP1 mRNA]PMID:30602124
Xbp1decreases splicingISOXBP1 (Homo sapiens)6480464CTDGlucosamine results in decreased splicing of XBP1 mRNAPMID:19383982
Xbp1increases expressionISOXbp1 (Rattus norvegicus)6480464CTDGlucosamine results in increased expression of XBP1 mRNAPMID:20165829
Xbp1increases expressionISOXBP1 (Homo sapiens)6480464CTDGlucosamine results in increased expression of XBP1 mRNAPMID:20165829
Xbp1increases splicingISOXBP1 (Homo sapiens)6480464CTDGlucosamine results in increased splicing of XBP1 mRNAPMID:33812996
Xbp1multiple interactionsISOXbp1 (Rattus norvegicus)6480464CTD4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased expression of XBP1 mRNA]; ursodoxicoltaurine inhibits the reaction [Glucosamine results in increased expression of XBP1 mRNA]PMID:20165829
Xbp1multiple interactionsISOXBP1 (Homo sapiens)6480464CTD4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased expression of XBP1 mRNA]; NUS1 protein inhibits the reaction [Glucosamine results in increased splicing of XBP1 mRNA]; ursodoxicoltaurine inhibits the reaction [Glucosamine results in increased expression of XBP1 mRNA]PMID:20165829 PMID:33812996
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