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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1332312
Species: Mus musculus
RGD Object: Gene
Symbol: Xbp1
Name: X-box binding protein 1
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Xbp1increases expressionEXP 6480464CTDLipopolysaccharides results in increased expression of XBP1 mRNA; Lipopolysaccharides results in increased expression of XBP1 proteinPMID:14600275 PMID:18483191 PMID:19675145
Xbp1increases splicingEXP 6480464CTDLipopolysaccharides results in increased splicing of XBP1 mRNAPMID:18483191
Xbp1multiple interactionsEXP 6480464CTDTetrachlorodibenzodioxin inhibits the reaction [Lipopolysaccharides results in increased expression of XBP1 mRNA]; Tetrachlorodibenzodioxin inhibits the reaction [Lipopolysaccharides results in increased expression of XBP1 protein]; Tetrachlorodibenzodioxin inhibits the reaction [Lipopolysaccharides results in increased splicing of XBP1 mRNA]PMID:14600275 PMID:18483191 PMID:19675145
Xbp1increases expressionISOXBP1 (Homo sapiens)6480464CTDLipopolysaccharides results in increased expression of XBP1 protein alternative formPMID:28245985
Xbp1multiple interactionsISOXBP1 (Homo sapiens)6480464CTD4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in increased expression of XBP1 protein alternative form]; [Estrogens, Conjugated (USP) co-treated with Lipopolysaccharides] results in increased expression of XBP1 mRNAPMID:28245985 PMID:31217279
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