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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1332312
Species: Mus musculus
RGD Object: Gene
Symbol: Xbp1
Name: X-box binding protein 1
Acc ID: CHEBI:110423
Term: clodronic acid
Definition: An organochlorine compound that is methylene chloride in which both hydrogens are replaced by phosphonic acid groups. It inhibits bone resorption and soft tissue calcification, and is used (often as the disodium salt tetrahydrate) as an adjunct in the treatment of severe hypercalcaemia associated with malignancy, and in the management of osteolytic lesions and bone pain associated with skeletal metastases.
Chemical ID: MESH:D004002
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Xbp1affects activityISOXBP1 (Homo sapiens)6480464CTDClodronic Acid affects the activity of XBP1 proteinPMID:25596134
Xbp1decreases expressionISOXBP1 (Homo sapiens)6480464CTDClodronic Acid results in decreased expression of XBP1 mRNAPMID:25596134
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