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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1322470
Species: Mus musculus
RGD Object: Gene
Symbol: Alox12
Name: arachidonate 12-lipoxygenase
Acc ID: CHEBI:7959
Term: D-penicillamine
Definition: An optically active form of penicillamine having D-configuration. Pharmaceutical form (L-form is toxic) of chelating agent used to treat heavy metal poisoning.
Chemical ID: MESH:D010396
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Alox12decreases expressionISOAlox12 (Rattus norvegicus)6480464CTDPenicillamine results in decreased expression of ALOX12 mRNAPMID:19575532
Alox12increases expressionISOAlox12 (Rattus norvegicus)6480464CTDPenicillamine results in increased expression of ALOX12 mRNAPMID:19575532
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