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GENE - TERM ANNOTATION REPORT

RGD ID: 1319195
Species: Mus musculus
RGD Object: Gene
Symbol: Stat6
Name: signal transducer and activator of transcription 6
Acc ID: GO:0060397
Term: growth hormone receptor signaling pathway via JAK-STAT
Definition: The process in which STAT proteins (Signal Transducers and Activators of Transcription) are activated by members of the JAK (janus activated kinase) family of tyrosine kinases, following the binding of physiological ligands to the growth hormone receptor. Once activated, STATs dimerize and translocate to the nucleus and modulate the expression of target genes.
Definition Source(s): GOC:BHF, GOC:dph, PMID:11445442
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Stat6involved_inIBAPANTHER:PTN002623856 or MGI:103036 or MGI:103035 or UniProtKB:P516922290270GO_Central GO_REF:0000033
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