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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1318438
Species: Mus musculus
RGD Object: Gene
Symbol: Shmt2
Name: serine hydroxymethyltransferase 2 (mitochondrial)
Acc ID: CHEBI:34372
Term: 4,4'-sulfonyldiphenol
Definition: A sulfone that is diphenyl sulfone in which both of the para hydrogens have been replaced by hydroxy groups.
Chemical ID: MESH:C543008
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Shmt2affects methylationEXP 6480464CTDbisphenol S affects the methylation of SHMT2 genePMID:31683443
Shmt2increases methylationEXP 6480464CTDbisphenol S results in increased methylation of SHMT2 exonPMID:33297965
Shmt2increases expressionISOSHMT2 (Homo sapiens)6480464CTDbisphenol S results in increased expression of SHMT2 proteinPMID:34186270
Shmt2multiple interactionsISOShmt2 (Rattus norvegicus)6480464CTD[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of SHMT2 mRNAPMID:36041667
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