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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1318438
Species: Mus musculus
RGD Object: Gene
Symbol: Shmt2
Name: serine hydroxymethyltransferase 2 (mitochondrial)
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Shmt2affects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of SHMT2 mRNAPMID:21570461
Shmt2increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of SHMT2 mRNAPMID:18796159
Shmt2multiple interactionsEXP 6480464CTD[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of SHMT2 mRNAPMID:16214954
Shmt2decreases expressionISOSHMT2 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in decreased expression of SHMT2 mRNAPMID:20106945 PMID:21632981
Shmt2increases expressionISOShmt2 (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in increased expression of SHMT2 mRNAPMID:33387578
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