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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1316728
Species: Mus musculus
RGD Object: Gene
Symbol: Rad51
Name: RAD51 recombinase
Acc ID: CHEBI:7719
Term: ochratoxin A
Definition: A phenylalanine derivative resulting from the formal condensation of the amino group of L-phenylalanine with the carboxy group of (3R)-5-chloro-8-hydroxy-3-methyl-1-oxo-3,4-dihydro-1H-2-benzopyran-7-carboxylic acid (ochratoxin alpha). It is among the most widely occurring food-contaminating mycotoxins, produced by Aspergillus ochraceus, Aspergillus carbonarius and Penicillium verrucosum.
Chemical ID: MESH:C025589
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Rad51decreases expressionISORAD51 (Homo sapiens)6480464CTDochratoxin A results in decreased expression of RAD51PMID:24525463
Rad51increases expressionISORad51 (Rattus norvegicus)6480464CTDochratoxin A results in increased expression of RAD51 mRNA; ochratoxin A results in increased expression of RAD51 proteinPMID:24243707 PMID:37162024
Rad51multiple interactionsISORAD51 (Homo sapiens)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [ochratoxin A results in decreased expression of RAD51]; SB 203580 inhibits the reaction [ochratoxin A results in decreased expression of RAD51]; TP53 mutant form inhibits the reaction [ochratoxin A results in decreased expression of RAD51]PMID:24525463
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