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GENE - TERM ANNOTATION REPORT

RGD ID: 1315878
Species: Mus musculus
RGD Object: Gene
Symbol: Piwil2
Name: piwi-like RNA-mediated gene silencing 2
Acc ID: GO:0140965
Term: secondary piRNA processing
Definition: A process leading to the generation of a functional secondary piRNA, involving a self-perpetuating piRNA loop, often called the ping-pong cycle, in which piRNAs are amplified by pairing with complementary transcripts (for example the transposable element mRNA target). In Drosophila, the processing involves the piwi proteins aubergine and Argonaute 3 and in mice, the piwi proteins Piwil2 and Piwil4.
Definition Source(s): PMID:29281264, PMID:32895365
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Piwil2involved_inIDA 2290270UniProt MGI:3815367 PMID:18922463 MGI:5908740 PMID:28633017

MGI:3815367 MGI:5908740 PMID:18922463 PMID:28633017
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