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GENE - TERM ANNOTATION REPORT

RGD ID: 1314001
Species: Homo sapiens
RGD Object: Gene
Symbol: PINK1
Name: PTEN induced kinase 1
Acc ID: DOID:0060369
Term: Parkinson's disease 6
Definition: An early-onset Parkinson's disease that has_material_basis_in mutations in the PINK1 gene on chromosome 1p36.12. (DO)
Definition Source(s): https://www.ncbi.nlm.nih.gov/pubmed/22315721 "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PINK1 IAGP 7240710OMIM  
PINK1 EXP 11554173CTDCTD Direct Evidence: marker/mechanismPMID:19048950 PMID:21421046 PMID:24475098 PMID:27003823
PINK1 IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Autosomal recessive early-onset Parkinson disease 6PMID:24033266 PMID:25627829
PINK1 IAGP (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Autosomal recessive early-onset Parkinson disease 6 | ClinVar Annotator: match by term: PARKINSON DISEASE 6, EARLY-ONSETPMID:25741868 PMID:26467025 PMID:28492532
PINK1 IAGP (Homo sapiens) or (Homo sapiens) or (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Autosomal recessive early-onset Parkinson disease 6PMID:26467025 PMID:28492532
PINK1 IAGP (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Autosomal recessive early-onset Parkinson disease 6PMID:25741868
PINK1 IAGP (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Autosomal recessive early-onset Parkinson disease 6PMID:28492532
PINK1 IAGP (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Autosomal recessive early-onset Parkinson disease 6 
PINK1 IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Autosomal recessive early-onset Parkinson disease 6PMID:18330912 PMID:18685134 PMID:23459931 PMID:26467025 PMID:28492532
PINK1 IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: PARKINSON DISEASE 6, EARLY-ONSETPMID:15349860 PMID:15596610 PMID:16009891 PMID:16547921 PMID:16969854 PMID:18330912 PMID:18546294 PMID:18685134 PMID:19087301 PMID:20558144 PMID:20981092 PMID:21925922 PMID:22644621 PMID:24167364 PMID:25741868 PMID:26274610 PMID:26467025 PMID:27884173 PMID:28492532
PINK1 IAGP (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Autosomal recessive early-onset Parkinson disease 6 | ClinVar Annotator: match by term: PARKINSON DISEASE 6, EARLY-ONSETPMID:25741868 PMID:28492532
PINK1 IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Autosomal recessive early-onset Parkinson disease 6PMID:16482571 PMID:28492532 PMID:33845304
PINK1 IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Autosomal recessive early-onset Parkinson disease 6PMID:15349860 PMID:18330912 PMID:19351622 PMID:19847793 PMID:23303188 PMID:23459931 PMID:25741868 PMID:28492532
PINK1 IAGP (Homo sapiens) or (Homo sapiens) or (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Autosomal recessive early-onset Parkinson disease 6PMID:17576681 PMID:28492532 PMID:9536098
PINK1 IAGP (Homo sapiens) or (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Autosomal recessive early-onset Parkinson disease 6PMID:15087508 PMID:15349870 PMID:23880019 PMID:28492532
PINK1 IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Autosomal recessive early-onset Parkinson disease 6PMID:18330912 PMID:28492532 PMID:33601107
PINK1 IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Autosomal recessive early-onset Parkinson disease 6PMID:16207217 PMID:18330912 PMID:25741868 PMID:28492532 PMID:33045815 PMID:33601107
PINK1 IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: PINK1-Related ParkinsonismPMID:15349860 PMID:16009891 PMID:23063710 PMID:23303188 PMID:23459931 PMID:25741868 PMID:28492532 PMID:33845304
PINK1 IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Autosomal recessive early-onset Parkinson disease 6PMID:15349870 PMID:17960343 PMID:18785233 PMID:20547144 PMID:25741868 PMID:28492532 PMID:29255601
PINK1 IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Autosomal recessive early-onset Parkinson disease 6PMID:16009891 PMID:23303188 PMID:25741868 PMID:28492532
PINK1 IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Autosomal recessive early-onset Parkinson disease 6PMID:26467025 PMID:28492532 PMID:32249012 PMID:32713623 PMID:33845304
PINK1 IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Autosomal recessive early-onset Parkinson disease 6PMID:15596610 PMID:16547921 PMID:16755580 PMID:19351622 PMID:21412950 PMID:22118943 PMID:22243833 PMID:22644621 PMID:24660942 PMID:25741868 PMID:26467025 PMID:27094865 PMID:28492532
PINK1 IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Autosomal recessive early-onset Parkinson disease 6PMID:15596610 PMID:16547921 PMID:16702191 PMID:16969854 PMID:18330912 PMID:18403612 PMID:19351622 PMID:19847793 PMID:22451330 PMID:22644621 PMID:24374372 PMID:25466404 PMID:25741868 PMID:28492532 PMID:28849312
PINK1 IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Autosomal recessive early-onset Parkinson disease 6PMID:25741868 PMID:26274610 PMID:28492532
PINK1 IAGP (Homo sapiens) or (Homo sapiens) or (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Autosomal recessive early-onset Parkinson disease 6PMID:17576681 PMID:25741868 PMID:28492532 PMID:9536098
PINK1 IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Autosomal recessive early-onset Parkinson disease 6PMID:15596610 PMID:16009891 PMID:16401616 PMID:19087301 PMID:20506312 PMID:22445250 PMID:23459931 PMID:24167364 PMID:25741868 PMID:26467025 PMID:28492532
PINK1 IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Autosomal recessive early-onset Parkinson disease 6PMID:18704525 PMID:28492532
PINK1 IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Autosomal recessive early-onset Parkinson disease 6PMID:17960343 PMID:26467025 PMID:28492532
PINK1 IAGP (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Autosomal recessive early-onset Parkinson disease 6PMID:15087508 PMID:15349870 PMID:28492532
PINK1 IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Autosomal recessive early-onset Parkinson disease 6PMID:16401616 PMID:16805805 PMID:16969854 PMID:18330912 PMID:18685134 PMID:19890973 PMID:28492532
PINK1 IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Autosomal recessive early-onset Parkinson disease 6PMID:16482571 PMID:20558144 PMID:21996382
PINK1 IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Autosomal recessive early-onset Parkinson disease 6PMID:15087508 PMID:15349870 PMID:24677602 PMID:28492532
PINK1 IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Autosomal recessive early-onset Parkinson disease 6PMID:16755580 PMID:18330912 PMID:25741868 PMID:28492532
PINK1 IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Autosomal recessive early-onset Parkinson disease 6PMID:17415511 PMID:25741868 PMID:28492532
PINK1 IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Autosomal recessive early-onset Parkinson disease 6PMID:16547921 PMID:16805805 PMID:16969854 PMID:17172567 PMID:18486522 PMID:20126261 PMID:2345993 PMID:23986421 PMID:28492532
PINK1 IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: PARKINSON DISEASE 6, EARLY-ONSETPMID:16547921 PMID:16805805 PMID:16969854 PMID:17172567 PMID:18486522 PMID:20126261 PMID:2345993 PMID:23986421 PMID:25741868 PMID:28492532
PINK1 IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Autosomal recessive early-onset Parkinson disease 6PMID:18330912 PMID:19889566 PMID:28492532
PINK1 IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Autosomal recessive early-onset Parkinson disease 6PMID:15349860 PMID:28492532 PMID:29091718
PINK1 IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Autosomal recessive early-onset Parkinson disease 6PMID:15349870 PMID:17960343 PMID:18785233 PMID:24677602 PMID:28492532
PINK1 IAGP (Homo sapiens) or (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Autosomal recessive early-onset Parkinson disease 6PMID:18330912 PMID:28492532
PINK1 IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Autosomal recessive early-onset Parkinson disease 6PMID:18541801 PMID:28492532
PINK1 IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Autosomal recessive early-onset Parkinson disease 6PMID:22644621 PMID:25741868 PMID:28492532
PINK1 IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Autosomal recessive early-onset Parkinson disease 6PMID:15087508 PMID:15349870 PMID:28492532 PMID:32713623
PINK1 IAGP (Homo sapiens) or (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Autosomal recessive early-onset Parkinson disease 6PMID:16401616 PMID:28492532
PINK1 IAGP (Homo sapiens) or (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Autosomal recessive early-onset Parkinson disease 6PMID:28492532 PMID:32713623
PINK1 IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Autosomal recessive early-onset Parkinson disease 6PMID:20558144 PMID:28492532
PINK1 IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Autosomal recessive early-onset Parkinson disease 6PMID:15596610 PMID:28492532
PINK1 IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Autosomal recessive early-onset Parkinson disease 6PMID:16401616 PMID:28492532 PMID:29655942 PMID:32446772
PINK1 IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Autosomal recessive early-onset Parkinson disease 6PMID:28492532 PMID:30502028 PMID:32713623
PINK1 IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Autosomal recessive early-onset Parkinson disease 6PMID:18286320 PMID:20798600 PMID:28492532
PINK1 IAGP (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Autosomal recessive early-onset Parkinson disease 6PMID:28492532
PINK1 IAGP (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Autosomal recessive early-onset Parkinson disease 6PMID:15087508 PMID:15349870 PMID:16199547 PMID:28492532
PINK1 IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Autosomal recessive early-onset Parkinson disease 6PMID:25741868 PMID:28492532 PMID:28849312
PINK1 IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Autosomal recessive early-onset Parkinson disease 6PMID:21534944 PMID:25741868 PMID:28492532 PMID:30502028 PMID:32713623
PINK1 IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Autosomal recessive early-onset Parkinson disease 6PMID:15349860 PMID:18330912
PINK1 IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Autosomal recessive early-onset Parkinson disease 6PMID:23459931
PINK1 IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Autosomal recessive early-onset Parkinson disease 6PMID:15584030 PMID:21488273 PMID:21925922 PMID:25741868 PMID:27094865 PMID:28492532
PINK1 IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Autosomal recessive early-onset Parkinson disease 6PMID:22764206
PINK1 IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Autosomal recessive early-onset Parkinson disease 6PMID:18685134 PMID:25741868 PMID:28492532
PINK1 IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Autosomal recessive early-onset Parkinson disease 6PMID:17576681 PMID:20356854 PMID:27574110 PMID:28492532 PMID:9536098
PINK1 IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Autosomal recessive early-onset Parkinson disease 6PMID:16257123 PMID:23459931 PMID:25741868 PMID:28492532 PMID:31217084 PMID:32713623
PINK1 IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Autosomal recessive early-onset Parkinson disease 6PMID:18330912 PMID:26467025 PMID:28492532
PINK1 IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Autosomal recessive early-onset Parkinson disease 6PMID:15349871
PINK1 IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Autosomal recessive early-onset Parkinson disease 6PMID:15955953
PINK1 IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Autosomal recessive early-onset Parkinson disease 6PMID:15087508 PMID:16207731 PMID:18003639
PINK1 IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Autosomal recessive early-onset Parkinson disease 6PMID:15349870
PINK1 IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Autosomal recessive early-onset Parkinson disease 6PMID:15087508 PMID:16207731 PMID:18524835
PINK1 IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Autosomal recessive early-onset Parkinson disease 6PMID:15349870 PMID:28492532
PINK1 IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Autosomal recessive early-onset Parkinson disease 6PMID:15349870 PMID:15596610 PMID:15824318 PMID:17055324 PMID:17579517 PMID:18359116 PMID:19242547 PMID:19880420 PMID:20798600 PMID:22644621 PMID:22956510 PMID:23303188 PMID:23334666 PMID:25558820 PMID:25741868 PMID:26467025 PMID:28492532 PMID:32861104 PMID:32870915 PMID:34159639 PMID:35844286 PMID:36774704
PINK1 IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Autosomal recessive early-onset Parkinson disease 6PMID:15970950 PMID:18704525 PMID:28492532 PMID:34148545
PINK1 IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Autosomal recessive early-onset Parkinson disease 6PMID:17030667 PMID:18541801 PMID:18785233 PMID:22238344 PMID:23303188 PMID:23459931 PMID:26274610 PMID:28492532 PMID:29255601
PINK1 IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Autosomal recessive early-onset Parkinson disease 6PMID:16966503
PINK1 IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Autosomal recessive early-onset Parkinson disease 6PMID:15087508 PMID:15349870 PMID:16769864 PMID:18685134 PMID:28492532 PMID:28502045
PINK1 IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Parkinson disease 6PMID:16969854
PINK1 IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Parkinson disease, autosomal recessive early-onset, digenic, PINK1/DJ1PMID:16632486 PMID:19229105 PMID:23459931
PINK1 ISSPink1 (Mus musculus)13592920MouseDOOMIM:605909 
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