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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1314001
Species: Homo sapiens
RGD Object: Gene
Symbol: PINK1
Name: PTEN induced kinase 1
Acc ID: CHEBI:16240
Term: hydrogen peroxide
Definition: An inorganic peroxide consisting of two hydroxy groups joined by a covalent oxygen-oxygen single bond.
Chemical ID: MESH:D006861
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PINK1affects response to substanceEXP 6480464CTDPINK1 protein affects the susceptibility to Hydrogen PeroxidePMID:21366594
PINK1decreases expressionEXP 6480464CTDHydrogen Peroxide results in decreased expression of PINK1 mRNAPMID:30316844
PINK1multiple interactionsEXP 6480464CTDBMAL1 protein affects the reaction [Polyphenols inhibits the reaction [Hydrogen Peroxide results in decreased expression of PINK1 mRNA]]; HMOX1 protein affects the reaction [PINK1 protein affects the susceptibility to Hydrogen Peroxide]; PINK1 protein affects the reaction [Hydrogen Peroxide results in increased expression of HMOX1 protein]; PINK1 protein affects the reaction [Hydrogen Peroxide results in increased expression of TRAP1 protein]; Polyphenols inhibits the reaction [Hydrogen Peroxide results in decreased expression of PINK1 mRNA]PMID:21366594 PMID:30316844
PINK1increases expressionISOPink1 (Rattus norvegicus)6480464CTDHydrogen Peroxide results in increased expression of PINK1 proteinPMID:21159781
PINK1multiple interactionsISOPink1 (Mus musculus)6480464CTDPINK1 protein affects the reaction [Hydrogen Peroxide results in increased chemical synthesis of Reactive Oxygen Species]PMID:21421046
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