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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1313355
Species: Mus musculus
RGD Object: Gene
Symbol: Nkx3-1
Name: NK3 homeobox 1
Acc ID: CHEBI:3090
Term: bicalutamide
Definition: A racemate comprising of equal amounts of (R)-bicalutamide and (S)-bicalutamide. It is an oral non-steroidal antiandrogen used in the treatment of prostate cancer and hirsutism.
Chemical ID: MESH:C053541
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nkx3-1decreases expressionISONKX3-1 (Homo sapiens)6480464CTDbicalutamide results in decreased expression of NKX3-1 mRNAPMID:15638997 PMID:28500234
Nkx3-1multiple interactionsISONKX3-1 (Homo sapiens)6480464CTD[Niclosamide co-treated with bicalutamide] results in decreased expression of NKX3-1 mRNA; bicalutamide inhibits the reaction [Antimony Potassium Tartrate results in increased expression of NKX3-1 mRNA]; bicalutamide inhibits the reaction [Cadmium Chloride results in increased expression of NKX3-1 mRNA]; bicalutamide inhibits the reaction [Metribolone results in increased expression of NKX3-1 mRNA]PMID:11751618 PMID:28500234 PMID:29462692
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