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GENE - TERM ANNOTATION REPORT

RGD ID: 1312846
Species: Mus musculus
RGD Object: Gene
Symbol: Cyfip2
Name: cytoplasmic FMR1 interacting protein 2
Acc ID: GO:0045202
Term: synapse
Definition: The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
Definition Source(s): GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyfip2is_active_inIBAPANTHER:PTN000257567 or MGI:1924134 or UniProtKB:Q96F07 or Cyfip1 (Rattus norvegicus) or MGI:13388012290270GO_Central GO_REF:0000033
Cyfip2located_inISOUniProtKB:Q96F072290270MGI PMID:11438699

PMID:11438699
Cyfip2is_active_inEXP 2290270SynGO PMID:34269176

PMID:34269176
Cyfip2is_active_inIDA 2290270SynGO PMID:11438699 PMID:34269176

PMID:11438699 PMID:34269176
Cyfip2is_active_inIEP 2290270SynGO PMID:11438699

PMID:11438699
Cyfip2is_active_inIMP 2290270SynGO PMID:34269176

PMID:34269176
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