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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1312098
Species: Mus musculus
RGD Object: Gene
Symbol: Hsd17b14
Name: hydroxysteroid (17-beta) dehydrogenase 14
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hsd17b14decreases expressionEXP 6480464CTDBenzo(a)pyrene results in decreased expression of HSD17B14 mRNAPMID:23735875
Hsd17b14increases methylationEXP 6480464CTDBenzo(a)pyrene results in increased methylation of HSD17B14 exon; Benzo(a)pyrene results in increased methylation of HSD17B14 intronPMID:27901495
Hsd17b14affects methylationISOHSD17B14 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of HSD17B14 5' UTR; Benzo(a)pyrene affects the methylation of HSD17B14 intronPMID:27901495 PMID:30157460
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