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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1310993
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tet1
Name: tet methylcytosine dioxygenase 1
Acc ID: CHEBI:17594
Term: hydroquinone
Definition: A benzenediol comprising benzene core carrying two hydroxy substituents para to each other.
Chemical ID: MESH:C031927
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tet1decreases expressionEXP 6480464CTDhydroquinone results in decreased expression of TET1 mRNAPMID:33188856
Tet1multiple interactionsEXP 6480464CTD[[Cadmium Chloride results in increased abundance of Cadmium] which co-treated with hydroquinone] results in decreased expression of TET1 mRNA; Acetylcysteine inhibits the reaction [[[Cadmium Chloride results in increased abundance of Cadmium] which co-treated with hydroquinone] results in decreased expression of TET1 mRNA]; Acetylcysteine inhibits the reaction [hydroquinone results in decreased expression of TET1 mRNA]PMID:33188856
Tet1multiple interactionsISOTET1 (Homo sapiens)6480464CTDhydroquinone results in increased expression of and results in increased activity of TET1 protein; TET1 protein affects the reaction [hydroquinone results in increased expression of GCLC mRNA]; TET1 protein affects the reaction [hydroquinone results in increased expression of SFN mRNA]PMID:23940045
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