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GENE - TERM ANNOTATION REPORT

RGD ID: 1309952
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mthfr
Name: methylenetetrahydrofolate reductase
Acc ID: DOID:11664
Term: nephrosclerosis
Definition: Hardening of the KIDNEY due to infiltration by fibrous connective tissue (FIBROSIS), usually caused by renovascular diseases or chronic HYPERTENSION. Nephrosclerosis leads to renal ISCHEMIA.
Definition Source(s): MESH:D009400
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mthfr ISOMTHFR (Homo sapiens)6893469RGDDNA:transition, transversion:cds:g.677C>T, g.1298A>C (human) 
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