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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1309952
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mthfr
Name: methylenetetrahydrofolate reductase
Acc ID: CHEBI:17230
Term: homocysteine
Definition: A sulfur-containing amino acid consisting of a glycine core with a 2-mercaptoethyl side-chain.
Chemical ID: MESH:D006710
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mthfraffects abundanceISOMthfr (Mus musculus)6480464CTDMTHFR protein affects the abundance of Homocysteine metabolitePMID:19204075
Mthfraffects metabolic processingISOMTHFR (Homo sapiens)6480464CTDMTHFR protein affects the metabolism of HomocysteinePMID:20547447
Mthfrdecreases methylationISOMTHFR (Homo sapiens)6480464CTDMTHFR protein SNP results in decreased methylation of HomocysteinePMID:17387702
Mthfrincreases abundanceISOMTHFR (Homo sapiens)6480464CTDMTHFR gene polymorphism results in increased abundance of Homocysteine; MTHFR protein mutant form results in increased abundance of HomocysteinePMID:19646848 PMID:7647779
Mthfrincreases expressionISOMthfr (Mus musculus)6480464CTDHomocysteine results in increased expression of MTHFR proteinPMID:18540024
Mthfrincreases expressionISOMTHFR (Homo sapiens)6480464CTDHomocysteine results in increased expression of MTHFR proteinPMID:18540024
Mthfrmultiple interactionsISOMthfr (Mus musculus)6480464CTD[MTHFR gene mutant form co-treated with Methotrexate] results in increased abundance of HomocysteinePMID:19593106
Mthfrmultiple interactionsISOMTHFR (Homo sapiens)6480464CTDHomocysteine inhibits the reaction [Simvastatin results in increased expression of MTHFR protein modified form]; Simvastatin promotes the reaction [Homocysteine results in increased expression of MTHFR protein]PMID:18540024
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