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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1309799
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hdac1
Name: histone deacetylase 1
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hdac1decreases expressionEXP 6480464CTDBenzo(a)pyrene results in decreased expression of HDAC1 proteinPMID:26358852
Hdac1decreases expressionISOHDAC1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of HDAC1 mRNAPMID:16269432
Hdac1multiple interactionsISOHdac1 (Mus musculus)6480464CTDBenzo(a)pyrene inhibits the reaction [[DNMT1 protein binds to HDAC1 protein] which binds to CYP1A1 promoter]; Benzo(a)pyrene inhibits the reaction [HDAC1 protein binds to CYP1A1 promoter]; Chromium inhibits the reaction [Benzo(a)pyrene inhibits the reaction [HDAC1 protein binds to CYP1A1 promoter]]PMID:14625279 PMID:17682057
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