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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1308913
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Zfp36l2
Name: zinc finger protein 36, C3H type-like 2
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Zfp36l2decreases expressionEXP 6480464CTDCisplatin results in decreased expression of ZFP36L2 mRNAPMID:22023808
Zfp36l2affects response to substanceISOZFP36L2 (Homo sapiens)6480464CTDZFP36L2 protein affects the susceptibility to CisplatinPMID:16217747
Zfp36l2decreases expressionISOZFP36L2 (Homo sapiens)6480464CTDCisplatin results in decreased expression of ZFP36L2 mRNAPMID:27594783
Zfp36l2decreases expressionISOZfp36l2 (Mus musculus)6480464CTDCisplatin results in decreased expression of ZFP36L2 mRNAPMID:21151649
Zfp36l2multiple interactionsISOZFP36L2 (Homo sapiens)6480464CTD[Piroxicam co-treated with Cisplatin] results in increased expression of ZFP36L2 mRNAPMID:21858171
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