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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1308542
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sirt1
Name: sirtuin 1
Acc ID: CHEBI:16196
Term: oleic acid
Definition: An octadec-9-enoic acid in which the double bond at C-9 has Z (cis) stereochemistry.
Chemical ID: MESH:D019301
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sirt1increases expressionEXP 6480464CTDOleic Acid results in increased expression of SIRT1 proteinPMID:24349266
Sirt1multiple interactionsEXP 6480464CTD[Ethanol co-treated with Oleic Acid co-treated with Palmitic Acid] results in decreased expression of SIRT1 proteinPMID:26854922
Sirt1decreases activityISOSIRT1 (Homo sapiens)6480464CTDOleic Acid results in decreased activity of SIRT1 proteinPMID:25536389
Sirt1multiple interactionsISOSIRT1 (Homo sapiens)6480464CTD6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [NAD promotes the reaction [Oleic Acid results in decreased activity of SIRT1 protein]]; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [Oleic Acid results in decreased activity of SIRT1 protein]; NAD promotes the reaction [Oleic Acid results in decreased activity of SIRT1 protein]PMID:25536389
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