Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1308374
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sirt3
Name: sirtuin 3
Acc ID: CHEBI:16236
Term: ethanol
Definition: A primary alcohol that is ethane in which one of the hydrogens is substituted by a hydroxy group.
Chemical ID: MESH:D000431
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sirt3increases expressionEXP 6480464CTDEthanol results in increased expression of SIRT3 mRNAPMID:18793633
Sirt3multiple interactionsEXP 6480464CTD1,3,7,9-tetramethyluric acid inhibits the reaction [[Dietary Fats co-treated with Ethanol co-treated with Carbon Tetrachloride] results in decreased expression of SIRT3 protein]; [Dietary Fats co-treated with Ethanol co-treated with Carbon Tetrachloride] results in decreased expression of SIRT3 protein; Resveratrol inhibits the reaction [Ethanol results in increased expression of SIRT3 mRNA]PMID:18793633 PMID:35872049
Sirt3increases metabolic processingISOSirt3 (Mus musculus)6480464CTDEthanol results in increased metabolism of SIRT3 proteinPMID:21449565
Go Back to source page   Continue to Ontology report