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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1308086
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Polr3e
Name: RNA polymerase III subunit E
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Polr3eaffects expressionISOPOLR3E (Homo sapiens)6480464CTDValproic Acid affects the expression of POLR3E mRNAPMID:25979313
Polr3eaffects expressionISOPolr3e (Mus musculus)6480464CTDValproic Acid affects the expression of POLR3E mRNAPMID:17292431
Polr3edecreases methylationISOPOLR3E (Homo sapiens)6480464CTDValproic Acid results in decreased methylation of POLR3E genePMID:29154799
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