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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1305332
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mdm2
Name: MDM2 proto-oncogene
Acc ID: CHEBI:75142
Term: N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal
Definition: A tripeptide that is L-leucyl-L-leucyl-L-leucine in which the C-terminal carboxy group has been reduced to the corresponding aldehyde and the N-terminal amino group is protected as its benzyloxycarbonyl derivative.
Chemical ID: MESH:C072553
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mdm2increases expressionISOMdm2 (Mus musculus)6480464CTDbenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of MDM2 mRNAPMID:20061341
Mdm2multiple interactionsISOMDM2 (Homo sapiens)6480464CTDbenzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Etoposide promotes the reaction [MDM2 protein binds to TOP2A protein]]PMID:17575151
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