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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1305332
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mdm2
Name: MDM2 proto-oncogene
Acc ID: CHEBI:46195
Term: paracetamol
Definition: A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Chemical ID: MESH:D000082
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mdm2decreases expressionEXP 6480464CTDAcetaminophen results in decreased expression of MDM2 mRNAPMID:21807079
Mdm2increases expressionEXP 6480464CTDAcetaminophen results in increased expression of MDM2 mRNAPMID:17202762 PMID:33387578
Mdm2increases phosphorylationEXP 6480464CTDAcetaminophen results in increased phosphorylation of MDM2 proteinPMID:16330492
Mdm2multiple interactionsEXP 6480464CTDAcetaminophen promotes the reaction [MDM2 protein binds to TP53 protein]PMID:16330492
Mdm2affects expressionISOMdm2 (Mus musculus)6480464CTDAcetaminophen affects the expression of MDM2 mRNAPMID:17562736
Mdm2decreases expressionISOMDM2 (Homo sapiens)6480464CTDAcetaminophen results in decreased expression of MDM2 mRNAPMID:21420995
Mdm2increases expressionISOMDM2 (Homo sapiens)6480464CTDAcetaminophen results in increased expression of MDM2 mRNAPMID:22230336
Mdm2increases expressionISOMdm2 (Mus musculus)6480464CTDAcetaminophen results in increased expression of MDM2 mRNAPMID:26056430
Mdm2multiple interactionsISOMdm2 (Mus musculus)6480464CTD[Clofibrate co-treated with Acetaminophen] affects the expression of MDM2 mRNA; PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of MDM2 mRNA]PMID:17585979
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